New treatments for restoring impaired epidermal barrier permeability: Skin barrier repair creams
Abstract
Skin health depends on an intact barrier composed of protein-rich corneocytes surrounded by the lamellar intercellular lipids. This barrier provides waterproof protection for the body, preventing infection, regulating electrolyte balance, maintaining body temperature, and providing a mechanism for sensation. Damage to the skin barrier results in skin disease that can be treated by a variety of externally applied substances, such as ceramides, hyaluronic acid, licorice extracts, dimethicone, petrolatum, and paraffin wax. These substances are found in moisturizers that are sold as cosmetics and in prescriptions as 510(k) devices. This contribution examines the formulation and effect of skin barrier creams.
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PN-HA treatments are well-tolerated and effective for repairing the skin barrier.
“PN-HA treatments are well-tolerated and effective for repairing the skin barrier [33,35,41].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [41]
PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes.
“PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes [21,24,31,32,33,34,35,40,41,42,150].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [41]
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- Authors
- Draelos, Z. D.
- Affiliations
- Duke University (US)
- Corresponding author
- Draelos, Zoe Diana
- ORCID
- Draelos, Zoe Diana
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 30
- Issue
- 3
- Pages
- 345-348
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W2042038628
- Cited by
- 78
- References
- 0
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 3 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- skin barrier repair, ceramide, hyaluronic acid, licorice extract, dimethicone, petrolatum, alkanes, corneocytes, intercellular lipids, emollients, topical formulation, skin disease treatment
- MeSH terms
- Administration, Topical, Cosmetics, Emollients, Epidermis, Humans, Permeability, Skin Absorption, Skin Diseases, Water Loss, Insensible, Wound Healing
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