Evoked potentials to nociceptive stimuli delivered by CO2 or Nd:YAP lasers
Abstract
Objective This study compares the amplitude, latency, morphology, scalp topography and intracranial generators of laser-evoked potentials (LEPs) to CO(2) and Nd:YAP laser stimuli.Methods LEPs were assessed in 11 healthy subjects (6 men, mean age 39+/-10 years) using a 32-channel acquisition system. Laser stimuli were delivered on the dorsum of both hands (intensity slightly above pain threshold), and permitted to obtain lateralised (N1) and vertex components (N2-P2) with similar scalp distribution for both types of lasers.Results The N1-YAP had similar latencies but significantly higher amplitudes relative to N1-CO(2). The N2-P2 complex showed earlier latencies, higher amplitudes (N2) and more synchronised responses when using Nd:YAP stimulation. The distribution of intracranial generators assessed with source localization analyses (sLORETA) was similar for Nd:YAP and CO(2) lasers. The insular, opercular, and primary sensorimotor cortices were active during the N1 time-window, whereas the anterior midcingulate, supplementary motor areas and mid-anterior insulae were active concomitant to the N2-P2 complex.Conclusions Earlier latencies and larger amplitudes recorded when using Nd:YAP pulses suggest a more synchronized nociceptive afferent volley with this type of laser.Significance This, together with its handy utilization due to optic fibre transmission, may favour the use of Nd:YAP lasers in clinical settings.
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The later N2 and P2 components reflect cortical generators in the insular and anterior cingulate cortices and largely represent cortical mechanisms that determine the subjective experience of pain.
“The later N2 and P2 components reflect cortical generators in the insular and anterior cingulate cortices 30, 63, and also relate to the intensity of noxious stimuli, although they largely represent cortical mechanisms that determine the subjective experience of pain 48.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [63]
The early N1 component reflects activity of cortical generators in the contralateral operculoinsular and primary somatosensory cortices and is largely driven by the magnitude of ascending nociceptive input, representing an early stage of sensory processing before the perceptual outcome is determined.
“The early N1 component, reflecting the activity of cortical generators in the contralateral operculoinsular and primary somatosensory cortices 30, 63, is largely driven by the magnitude of the ascending nociceptive input, representing an early stage of sensory processing before the perceptual outcome of the nociceptive input is determined 48, 64, 65.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [63]
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References 54 · Cited by 88
- Authors
- Perchet, C., Godinho, F., Mazza, S., Frot, M., Legrain, V., Magnin, M., & Garcia-Larrea, L.
- Affiliations
- Inserm (FR)
- Düsseldorf University Hospital (DE)
- Corresponding author
- Perchet, Caroline
- Venue
- Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 119
- Issue
- 11
- Pages
- 2615-2622
- ISSN
- 1388-2457 (ISSN-L)
- OpenAlex
- W2164613875
- Cited by
- 88
- References
- 54
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 10 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 3 · 2012: 7
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Laser Applications in Dentistry and Medicine
- Keywords
- laser-evoked potentials, nociceptive stimuli, CO2 laser, Nd:YAP laser, pain threshold, N1 component, source localization, sLORETA, insula, anterior midcingulate cortex, supplementary motor area, scalp topography
- MeSH terms
- Adult, Brain Mapping, Electroencephalography, Electromyography, Evoked Potentials, Somatosensory, Female, Humans, Functional Laterality, Male, Middle Aged, Pain, Reaction Time, Pain Threshold, Lasers, Gas
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