A meta-analysis of cortical inhibition and excitability using transcranial magnetic stimulation in psychiatric disorders
Abstract
Objective To evaluate transcranial magnetic stimulation (TMS) measures of inhibition and excitation in obsessive-compulsive disorder (OCD), major depressive disorder (MDD) and schizophrenia (SCZ).Methods Paradigms included: short-interval cortical inhibition (SICI), cortical silent period (CSP), resting motor threshold, intracortical facilitation, and motor evoked potential amplitude. A literature search was performed using PubMed, Ovid Medline, Embase Psychiatry and PsycINFO 1990 through April 2012.Results A significant Hedge's g was found for decreased SICI (g=0.572, 95% confidence interval [0.179, 0.966], p=0.004), enhanced intracortical facilitation (g=0.446, 95% confidence interval [0.042, 0.849], p=0.030) and decreased CSP (g=-0.466, 95% confidence interval [-0.881, -0.052], p=0.027) within the OCD population. For MDD, significant effect sizes were demonstrated for decreased SICI (g=0.641, 95% confidence interval [0.384, 0.898], p=0.000) and shortened CSP (g=-1.232, 95% confidence interval [-1.530, -0.933], p=0.000). In SCZ, a significant Hedge's g was shown for decreased SICI (g=0.476, 95% confidence interval [0.331, 0.620], p=0.000).Conclusion Inhibitory deficits are a ubiquitous finding across OCD, MDD, SCZ and enhancement of intracortical facilitation is specific to OCD.Significance Provides a clear platform from which diagnostic procedures can be developed.
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Short-interval cortical inhibition (SICI) is significantly reduced in schizophrenia patients compared with healthy subjects (d = 0.476).
“A recent meta-analysis 74 reported that SICI was significantly reduced in SCZ patients when compared with healthy subjects (d = 0.476).”
From Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain? (2016) · cites this paper as [74]
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References 82 · Cited by 186
- Authors
- Radhu, N., de Jesus, D. R., Ravindran, L. N., Zanjani, A., Fitzgerald, P. B., & Daskalakis, Z. J.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- The Alfred Hospital (AU)
- Corresponding author
- Daskalakis, Zafiris J.
- Venue
- Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 124
- Issue
- 7
- Pages
- 1309-1320
- ISSN
- 1388-2457 (ISSN-L)
- OpenAlex
- W2101900692
- Cited by
- 186
- References
- 82
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 17 · 2023: 12 · 2022: 11 · 2021: 23 · 2020: 13 · 2019: 23 · 2018: 16 · 2017: 13 · 2016: 18 · 2015: 11 · 2014: 19 · 2013: 2
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- National Health and Medical Research Council
- Brain and Behavior Research Foundation
- Centre for Addiction and Mental Health
- Ontario Mental Health Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- cortical inhibition, cortical excitability, obsessive-compulsive disorder, major depressive disorder, schizophrenia, short-interval intracortical inhibition, cortical silent period, intracortical facilitation, resting motor threshold, motor evoked potentials, inhibitory deficits, mental illness
- MeSH terms
- Mental Disorders, Major Depressive Disorder, Female, Humans, Male, Motor Cortex, Neural Inhibition, Obsessive-Compulsive Disorder, Reaction Time, Schizophrenia, Time Factors, Databases, Factual, Evoked Potentials, Motor, Transcranial Magnetic Stimulation
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