Atypical auditory language processing in adolescents with autism spectrum disorder
Abstract
Objective Individuals with autism spectrum disorder (ASD) often show characteristic differences in auditory processing. To clarify the mechanisms underlying communication impairment in ASD, we examined auditory language processing with both anatomical and functional methods. Methods We assessed the language abilities of adolescents with ASD and typically developing (TD) adolescents, and analyzed the surface-based morphometric structure between the groups using magnetic resonance imaging. Furthermore, we measured cortical responses to an auditory word comprehension task with magnetoencephalography and performed network-based statistics using the phase locking values. Results We observed no structural differences between the groups. However, the volume of the left ventral central sulcus (vCS) showed a significant correlation with linguistic scores in ASD. Moreover, adolescents with ASD showed weaker cortical activation in the left vCS and superior temporal sulcus. Furthermore, these regions showed differential correlations with linguistic scores between the groups. Moreover, the ASD group had an atypical gamma band (25-40 Hz) network centered on the left vCS. Conclusions Adolescents with ASD showed atypical responses on the auditory word comprehension task and functional brain differences. Significance Our results suggest that phonological processing and gamma band cortical activity play a critical role in auditory language processing-related pathophysiology in adolescents with ASD.
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Severity of sensory processing deficits in ASD is correlated with reduced inter-hemispheric connectivity of auditory cortices and lower verbal IQ.
“The severity of sensory processing deficits in ASD also seems to be correlated with reduced inter-hemispheric connectivity of auditory cortices (Linke et al. 2018; Tanigawa et al. 2018) and lower verbal IQ (Linke et al. 2018).”
From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Tanigawa et al. 2018
Increased connectivity between the thalamus and the auditory cortex is found in patients with reduced cognitive and behavioral symptomatology.
“Interestingly, increased connectivity between the thalamus and the auditory cortex was found in patients with reduced cognitive and behavioral symptomatology (Linke et al. 2018; Tanigawa et al. 2018), which suggests high thalamocortical connectivity as a potential compensatory mechanism in ASD (Linke et al. 2018).”
From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Tanigawa et al. 2018
Adolescents diagnosed with ASD show weaker cortical activation in the left ventral central sulcus at word comprehension tasks.
“Adolescents diagnosed with ASD show weaker cortical activation in the left ventral central sulcus at word comprehension tasks (Tanigawa et al. 2018), indicating atypical hemispheric functional asymmetries.”
From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Tanigawa et al. 2018
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- Authors
- Tanigawa, J., Kagitani-Shimono, K., Matsuzaki, J., Ogawa, R., Hanaie, R., Yamamoto, T., Tominaga, K., Nabatame, S., Mohri, I., Taniike, M., & Ozono, K.
- Affiliations
- The University of Osaka (JP)
- Molecular Research Center for Children's Mental Development (JP)
- ORCID
- Venue
- Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 129
- Issue
- 9
- Pages
- 2029-2037
- ISSN
- 1388-2457 (ISSN-L)
- OpenAlex
- W2807276919
- Cited by
- 17
- References
- 9
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (JP26870333, JP23591394)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, auditory language processing, adolescents, superior temporal sulcus, gamma oscillations, phonological processing, cortical activation, brain network analysis, phase locking, communication disorders
- MeSH terms
- Autism Spectrum Disorder, Adolescent, Auditory Perception, Auditory Perceptual Disorders, Brain, Brain Mapping, Child, Humans, Male, Nerve Net, Magnetoencephalography
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