Liver physiological polyploidization: MicroRNA-122 a key regulator
Abstract
Polyploidy is defined as an increase in genome DNA content and is observed in all mammalian species. Polyploidy is a common characteristic of hepatocytes. Polyploidization occurs mainly during liver development, but also in adults with increasing age or due to cellular stress. During liver development, hepatocytes polyploidization occurs through cytokinesis failure leading to the genesis of binucleate hepatocytes. Recently, Hsu et al. demonstrated that miR-122 is a key regulator of hepatic binucleation. In fact, during liver development, miR-122 directly antagonizes procytokinesis targets and thus induces cytokinesis failure leading to the genesis of binucleate hepatocytes.
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A postnatal surge in miR-122 is required for the physiological polyploidization of hepatocytes.
“This was particularly interesting because a postnatal surge in miR-122 is required for the physiological polyploidization of hepatocytes (Hsu et al. 2016; Celton-Morizur and Desdouets 2017).”
From ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation (2025) · cites this paper as Celton-Morizur and Desdouets 2017
Cites
Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes
Guidotti, J.-E., Brégerie, O., Robert, A., Debey, P., Brechot, C., & Desdouets, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300982200 · Cited by 315 · see citing works
Self-citationCelton-Morizur, S., Merlen, G., Couton, D., Margall-Ducos, G., & Desdouets, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38677 · Cited by 145 · see citing works
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ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation
Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2025) · Genes & Development · doi:10.1101/gad.352129.124 · Cited by 4 · see citing works
- Authors
- Celton-Morizur, S., & Desdouets, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Desdouets, Chantal
- ORCID
- Desdouets, Chantal
- Venue
- Clinics and Research in Hepatology and Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 41
- Issue
- 2
- Pages
- 123-125
- ISSN
- 2210-7401 (ISSN-L)
- OpenAlex
- W2581693344
- Cited by
- 5
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2018: 1 · 2017: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics and Research in Hepatology and Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- polyploidy, hepatocytes, miR-122, cytokinesis failure, liver development, microRNA regulation
- MeSH terms
- Animals, Cell Nucleus, Humans, Liver, Polyploidy, Hepatocytes, MicroRNAs
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