The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Use of Biologics in Rheumatoid Arthritis: Current and Emerging Paradigms of Care
Open accessAbstract
Background Rheumatoid arthritis (RA) is a common inflammatory autoimmune disease that places a substantial burden on health care systems. Although there is currently no cure for RA, improved understanding of RA disease pathogenesis in recent years has led to the development of new biologic treatments designed to target specific elements of the RA inflammatory response. Objective To provide individuals responsible for decision making within managed care environments, including pharmacists, physicians, and other healthcare professionals, with a review of biologic therapies currently used for the treatment of RA. Investigational treatments for RA are also discussed. Methods A narrative review of the peer-reviewed, published literature on biologic therapies in the treatment of RA was performed. Results The treatment of RA is aimed at achieving the lowest possible disease activity and ideally remission. Biologic agents that target specific components of the immune response are highly effective in reducing RA symptoms, slowing the rate of disease progression, and improving physical function and quality of life measures in patients with moderate to severe RA. Dosing schedules and routes of administration vary depending on the biologic used, and these factors influence the cost of therapy and patient and physician preference. Conclusion The treatment of RA has been transformed in the last decade with the introduction of several targeted biologic agents. Although biologic agents are more costly in the short term than conventional disease-modifying antirheumatic drugs, drug-specific costs may be offset by significant improvements in RA symptoms, slowed disease progression, and improved physical function and quality of life for patients.
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Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis
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A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis
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Cited by
Management of Rheumatoid Arthritis: An Overview
Radu, A.-F., & Bungau, S. G. (2021) · Cells · doi:10.3390/cells10112857 · Cited by 1,089
Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis
Taylor, P. C., Keystone, E. C., van der Heijde, D., Weinblatt, M. E., del Carmen Morales, L., Reyes Gonzaga, J., Yakushin, S., Ishii, T., Emoto, K., Beattie, S., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1608345 · Cited by 872
Yun, H., Xie, F., Delzell, E., Levitan, E. B., Chen, L., Lewis, J. D., Saag, K. G., Beukelman, T., Winthrop, K. L., Baddley, J. W., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39399 · Cited by 152
Self-citation
Metadata
- Authors
- Curtis, J. R., & Singh, J. A.
- Venue
- Clinical Therapeutics
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 33
- Issue
- 6
- Pages
- 679-707
- ISSN
- 0149-2918 (ISSN-L)
- OpenAlex
- W2038593306
- Cited by
- 326
- References
- 83
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- green
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