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Cited by 382Gut microbiota and healthGastrointestinal motility and disordersClinical Nutrition and Gastroenterology

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

Bloemen, Johanne G., Venema, Koen, van de Poll, Marcel C., Olde Damink, Steven W., Buurman, Wim A., Dejong, Cornelis H.·2009·Clinical Nutrition
DOI 10.1016/j.clnu.2009.05.011
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Abstract

Background & aims Short chain fatty acids (SCFAs; acetate, propionate and butyrate) are important energy sources for colonocytes and are assumed to play a key role in gut health. Local effects of SCFAs have been investigated, but less is known about whole body metabolism of these SCFAs. The aim of the present study was to quantify the role of the gut and liver in interorgan exchange of SCFAs in humans in vivo. Methods Twenty-two patients undergoing major upper abdominal surgery were studied. Blood was sampled from a radial artery, the portal and a hepatic vein. Portal, splanchnic and arterial blood flow was measured using intra-operative Duplex ultrasonography. SCFAs were measured on a liquid chromatography system combined with mass spectrometry. Results SCFAs were released by the gut, 34.9 (9.1) micromol kg bodyweight(-1)h(-1). SCFAs uptake by the liver was significant for propionate and butyrate; -5.6 (1.3) and -3.8 (1.6) micromol kg bodyweight(-1)h(-1) (p=0.0002 and p=0.03) respectively and counterbalanced gut release. Liver uptake of acetate was not significant, -5.2 (6.6) micromol kg bodyweight(-1)h(-1) (p=0.434). Splanchnic (i.e., gut+liver) SCFAs release was significant for acetate and propionate, 17.3 (7.3) and 1.2 (0.4) micromol kg bodyweight(-1)h(-1) (p=0.027 and p=0.0038), respectively. Splanchnic release of butyrate was not significantly different from zero (1.9 (1.2) micromol kg bodyweight(-1)h(-1), p=0.129). BMI and previous colonic resection did not affect gut…

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  • The remainder of butyrate and the majority of propionate are metabolized by hepatocytes, resulting in 1-15 μmol/L concentrations of propionate and butyrate in circulation, whereas acetate is found at 100-200 μmol/L.

    “The remainder of butyrate, as well as the majority of propionate, is subsequently metabolized by hepatocytes, resulting in 1-to 15-µmol/L concentrations of propionate and butyrate in circulation, whereas acetate is found within a range of 100-200 µmol/L (Bloemen et al., 2009;Cummings et al., 1987;Peters et al.,”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Bloemen et al., 2009

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References 29 · Cited by 382

Authors
Bloemen, J. G., Venema, K., van de Poll, M. C., Olde Damink, S. W., Buurman, W. A., & Dejong, C. H.
Affiliations
  • Maastricht University Medical Centre (NL)
  • TiFN (NL)
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2009-12
Volume
28
Issue
6
Pages
657-661
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2009.05.011
OpenAlex
W1993037755
Cited by
382
References
29
Citations by year
2026: 27 · 2025: 35 · 2024: 28 · 2023: 32 · 2022: 46 · 2021: 49 · 2020: 31 · 2019: 30 · 2018: 19 · 2017: 16 · 2016: 23 · 2015: 15 · 2014: 5 · 2013: 5 · 2012: 5
FWCI
2.68
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Funders
ZonMw
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
short-chain fatty acids, acetate, propionate, butyrate, hepatic uptake, intestinal release, splanchnic circulation, portal vein, hepatic vein, colectomy, colonic fermentation, whole-body metabolism
MeSH terms
Adult, Aged, Algorithms, Fatty Acids, Volatile, Female, Hepatic Veins, Humans, Intestinal Absorption, Intestinal Mucosa, Intestines, Intraoperative Period, Liver, Male, Middle Aged, Portal Vein, Regional Blood Flow, Spleen, Body Mass Index, Radial Artery, Ultrasonography, Doppler

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