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Cited by 53Celiac Disease Research and ManagementWheat and Barley Genetics and PathologyFood composition and properties

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Evaluation of the safety of ancient strains of wheat in coeliac disease reveals heterogeneous small intestinal T cell responses suggestive of coeliac toxicity

Šuligoj, Tanja, Gregorini, Armando, Colomba, Mariastella, Ellis, H. Julia, Ciclitira, Paul J.·2013·Clinical Nutrition
DOI 10.1016/j.clnu.2013.02.003
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Abstract

Background & aims Coeliac disease is a chronic small intestinal immune-mediated enteropathy triggered by dietary gluten in genetically predisposed individuals. Since it is unknown if all wheat varieties are equally toxic to coeliac patients seven Triticum accessions showing different origin (ancient/modern) and ploidy (di-, tetra- hexaploid) were studied. Materials and methods Selected strains of wheat were ancient Triticum monococcum precoce (AA genome) and Triticum speltoides (BB genome), accessions of Triticum turgidum durum (AABB genome) including two ancient (Graziella Ra and Kamut) and two modern (Senatore Cappelli and Svevo) durum strains of wheat and Triticum aestivum compactum (AABBDD genome). Small intestinal gluten-specific T-cell lines generated from 13 coeliac patients were tested with wheat accessions by proliferation assays. Results All strains of wheat independent of ploidy or ancient/modern origin triggered heterogeneous responses covering wide ranges of stimulation indices. Conclusion Ancient strains of wheat, although previously suggested to be low or devoid of coeliac toxicity, should be tested for immunogenicity using gluten-specific T-cell lines from multiple coeliac patients rather than gluten-specific clones to assess their potential toxicity. Our findings provide further evidence for the need for a strict gluten-free diet in coeliac patients, including avoidance of ancient strains of wheat.

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Metadata

Authors
Šuligoj, T., Gregorini, A., Colomba, M., Ellis, H. J., & Ciclitira, P. J.
Affiliations
  • St Thomas' Hospital (GB)
  • University of Urbino (IT)
Corresponding author
  • Šuligoj, Tanja
  • Gregorini, Armando
  • Colomba, Mariastella
  • Ellis, H. Julia
  • Ciclitira, Paul J.
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2013-12
Volume
32
Issue
6
Pages
1043-1049
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2013.02.003
OpenAlex
W1985338045
Cited by
53
References
0
Citations by year
2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 4
FWCI
5.04
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
Funders
Rosetrees Trust
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Keywords
celiac disease, Triticum monococcum, Aegilops speltoides, durum wheat, wheat, gluten-free diet
MeSH terms
Adult, Aged, Celiac Disease, Female, Glutens, Humans, Intestine, Small, Male, Middle Aged, T-Lymphocytes, Triticum, Cell Proliferation, Young Adult

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