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Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken
Open accessAbstract
FLASH radiotherapy (FLASH-RT) is a technology that could modify the way radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of radiotherapy at dose rates several orders of magnitude higher than those currently used in routine clinical practice. This very short time of exposure leads to the striking observation of relative protection of normal tissues that are exposed to FLASH-RT as compared with conventional dose rate radiotherapy. Here we summarise the current knowledge about the FLASH effect and provide a synthesis of the observations that have been reported on various experimental animal models (mice, zebrafish, pig, cats), various organs (lung, gut, brain, skin) and by various groups across 40 years of research. We also propose possible mechanisms for the FLASH effect, as well as possible paths for clinical application.
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Cited by
Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?
Wilson, J. D., Hammond, E. M., Higgins, G. S., & Petersson, K. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01563 · Cited by 473
Towards clinical translation of FLASH radiotherapy
Vozenin, M.-C., Bourhis, J., & Durante, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00697-z · Cited by 363
Self-citationFLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy
Hughes, J. R., & Parsons, J. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186492 · Cited by 267
Mostafavi, M., Ghazi, F., Mehrabifard, M., Alivirdiloo, V., Hajiabbasi, M., Rahimi, F., Mobed, A., Taheripak, G., Ramezani Farani, M., Huh, Y. S., et al. (2025) · Strahlentherapie und Onkologie · doi:10.1007/s00066-024-02301-y · Cited by 16
Metadata
- Authors
- Vozenin, M.-C., Hendry, J. H., & Limoli, C. L.
- Venue
- Clinical Oncology
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 31
- Issue
- 7
- Pages
- 407-415
- ISSN
- 0936-6555 (ISSN-L)
- OpenAlex
- W2936488270
- Cited by
- 484
- References
- 0
- FWCI
- 41.18
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken. https://app.cochat.ai/papers/10.1016/j.clon.2019.04.001
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- Vozenin, M.-C., Hendry, J. H., & Limoli, C. L. (2019). Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken. Clinical Oncology. https://doi.org/10.1016/j.clon.2019.04.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
