Long-Term Impact of Preterm Birth
Abstract
Preterm birth severely disrupts the normal developmental maturation of organ systems, resulting in lasting adverse effects. High blood pressure, cardiac dysfunction, obstructive lung disease, elevated blood glucose, and mental health problems occur earlier and at higher rates in the preterm-born than in the term populations. Disadvantageous health conditions may have a significant impact on the well-being of preterm-born individuals from childhood through adulthood. This review summarizes the impact of preterm birth on neurodevelopment and on cardiovascular, renal, metabolic, and pulmonary health.
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Current studies support measurable biological embedding during fetal life, but they do not yet provide validated causal or prognostic markers for adult disease.
“Current studies support measurable biological embedding during fetal life [73,80,115], but they do not yet provide validated causal or prognostic markers for adult disease.”
From Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures (2026) · cites this paper as [115]
Cites
Cognitive and Behavioral Outcomes of School-Aged Children Who Were Born Preterm: A Meta-analysis
Bhutta, A. T., Cleves, M. A., Casey, P. H., Cradock, M. M., & Anand, K. J. S. (2002) · JAMA · doi:10.1001/jama.288.6.728 · Cited by 2,392 · see citing works
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Sedentary behaviour and physical activity across pregnancy and birth outcomes
Jones, M. A., Catov, J. M., Jeyabalan, A., Whitaker, K. M., & Barone Gibbs, B. (2021) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12731 · Cited by 37 · see citing works
Panteris, E., Kakatsaki, I., Koukou, Z., Kolvatzis, C., Papanikolaou, S., & Hatzidaki, E. (2026) · Pathophysiology · doi:10.3390/pathophysiology33030067
- Authors
- Luu, T. M., Rehman Mian, M. O., & Nuyt, A. M.
- Affiliations
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Corresponding author
- Luu, Thuy Mai
- Venue
- Clinics in Perinatology
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 44
- Issue
- 2
- Pages
- 305-314
- ISSN
- 0095-5108 (ISSN-L)
- OpenAlex
- W2596030705
- Cited by
- 278
- References
- 1
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 42 · 2023: 46 · 2022: 53 · 2021: 36 · 2020: 26 · 2019: 15 · 2018: 12 · 2017: 2
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- preterm birth, long-term outcomes, brain development, cardiovascular health, kidney health, metabolic health, respiratory health, hypertension, cardiac dysfunction, obstructive lung disease, hyperglycemia, mental health, developmental maturation
- MeSH terms
- Cardiovascular Diseases, Humans, Infant, Newborn, Infant, Premature, Insulin Resistance, Lung Diseases, Obstructive, Time, Metabolic Syndrome, Premature Birth, Renal Insufficiency, Chronic, Infant, Extremely Premature, Neurodevelopmental Disorders
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