Adiponectin: Starving for Attention
Open accessAbstract
Maintaining energy balance involves the dynamic control of appetite and energy expenditure. A new study from the Kadowaki laboratory (Kubota et al., 2007) shows that the adipocyte-derived hormone adiponectin increases appetite and reduces energy expenditure by stimulating AMPK in the hypothalamus.
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In the brain, adiponectin activates AMPK signaling in hypothalamic ARC, resulting in an increase in food intake and a reduction in energy expenditure, suggesting that in the hypothalamus adiponectin promotes feeding and inhibits the anorexigenic effects of leptin.
“In the brain, adiponectin activates AMPK signaling in hypothalamic ARC, resulting in an increase in food intake and a reduction in energy expenditure, suggesting that in the hypothalamus adiponectin promotes feeding and inhibits the anorexigenic effects of leptin 55, 56.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [55]
Adiponectin levels increase in low glucose and low insulin conditions, at least in the cerebrospinal fluid.
“In contrast to leptin, adiponectin levels increase in low glucose and low insulin conditions, at least in the cerebrospinal fluid (CSF) 55, 56.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [55]
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References 10 · Cited by 23
- Authors
- Steinberg, G. R., & Kemp, B. E.
- Affiliations
- The University of Melbourne (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Corresponding author
- Steinberg, Gregory R.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 6
- Issue
- 1
- Pages
- 3-4
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1964603672
- Cited by
- 23
- References
- 10
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adiponectin, appetite regulation, energy expenditure, energy balance, AMPK, hypothalamus, adipocytes, adipokines
- MeSH terms
- Animals, Eating, Energy Metabolism, Hypothalamus, Multienzyme Complexes, Protein Serine-Threonine Kinases, Adiponectin, AMP-Activated Protein Kinases
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