A Balance of Lipid-Sensing Mechanisms in the Brain and Liver
Open accessAbstract
Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-sensing mechanisms in the brain and liver reveals similar biochemical/molecular but opposing physiological mechanisms in operation. We propose that an imbalance between the lipid-sensing mechanisms in the brain and liver may contribute to obesity-associated type 2 diabetes.
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CNS nutrient-sensing plays an important role in the regulation of energy balance and glucose metabolism.
“Nutrient-sensing involving in the CNS play an important role in the regulation of energy balance and glucose metabolism”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [31]
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References 55 · Cited by 58
Research works printed but not linked: 2
- Dobbins, R.L., Szczepaniak, L.S., Bentley, B., Esser, V., Myhill, J., and McGarry, J.D. (2001). Diabetes 50, 123-130. Cell Metabolism 6, August 2007 ª2007 Elsevier Inc. 103
- Kim, J.K., Fillmore, J.J., Chen, Y., Yu, C., Moore, I.K., Pypaert, M., Lutz, E.P., Kako, Y., Velez-Carrasco, W., Goldberg, I.J., et al. (2001). Proc. Natl. Acad. Sci. USA 98, 7522- 7527.
- Authors
- Caspi, L., Wang, P. Y. T., & Lam, T. K. T.
- Affiliations
- University Health Network (CA)
- Corresponding author
- Lam, Tony K.T.
- ORCID
- Lam, Tony K.T.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 6
- Issue
- 2
- Pages
- 99-104
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2022362070
- Cited by
- 58
- References
- 55
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- J.P. Bickell Foundation
- University of Toronto
- Canadian Institutes of Health Research
- Banting and Best Diabetes Centre, University of Toronto
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- lipid sensing, brain, liver, nutrient sensing, obesity, type 2 diabetes, metabolic regulation, lipid metabolism
- MeSH terms
- Animals, Brain, Diabetes Mellitus, Humans, Insulin, Liver, Obesity, Models, Animal, Lipid Metabolism
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