Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

Dong, Xiaocheng C.; Copps, Kyle D.; Guo, Shaodong; Li, Yedan; Kollipara, Ramya; DePinho, Ronald A.; White, Morris F.

doi:10.1016/j.cmet.2008.06.006

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

Summary The Forkhead transcription factor Foxo1 regulates expression of genes involved in stress resistance and metabolism. To assess the contribution of Foxo1 to metabolic dysregulation during hepatic insulin resistance, we disrupted Foxo1 expression in the liver of mice lacking hepatic Irs1 and…