Estrogens and Obesity: Is It All in Our Heads?
Open accessAbstract
Estrogens have preventative effects on weight gain and associated comorbidities, but the tissue-specific targets remain unknown. Here, Xu et al. (2011) demonstrate that ablation of estrogen signaling in two populations of hypothalamic neurons leads to weight gain and subsequent metabolic dysregulation and could be important target sites of estrogen actions.
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Estrogens directly and indirectly modulate the activity of molecules involved in orexigenic action, which induces an increase in food intake.
“Estrogens directly and indirectly modulate the activity of molecules involved in orexigenic action, which induces an increase in food intake [89, 90].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [90]
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References 9 · Cited by 22
- Authors
- Hart-Unger, S., & Korach, K. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Korach, Kenneth S.
- ORCID
- Korach, Kenneth S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 14
- Issue
- 4
- Pages
- 435-436
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4166555
- OpenAlex
- W1980647758
- Cited by
- 22
- References
- 9
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 1
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (ZIAES070065)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen, obesity, hypothalamic neurons, estrogen signaling, weight gain, metabolic dysfunction
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