Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

Coupé, Bérengère; Ishii, Yuko; Dietrich, Marcelo O.; Komatsu, Masaaki; Horvath, Tamas L.; Bouret, Sebastien G.

doi:10.1016/j.cmet.2011.12.016

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

Summary The hypothalamic melanocortin system, which includes neurons that produce proopiomelanocortin (POMC)-derived peptides, is a major negative regulator of energy balance. POMC neurons begin to acquire their unique properties during neonatal life. The formation of functional neural systems re…