Metabolic Regulation of Epigenetics
Open accessAbstract
How cells sense and respond to environmental cues remains a central question of biological research. Recent evidence suggests that DNA transcription is regulated by chromatin organization. However, the mechanism for relaying the cytoplasmic signaling to chromatin remodeling remains incompletely understood. Although much emphasis has been put on delineating transcriptional output of growth factor/hormonal signaling pathways, accumulated evidence from yeast and mammalian systems suggest that metabolic signals also play critical roles in determining chromatin structure. Here we summarize recent progress in understanding the molecular connection between metabolism and epigenetic modifications of chromatin implicated in a variety of diseases including cancer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glucose is a key molecule in transcriptional processes.
“Glucose is a key molecule in transcriptional processes.”
From 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience (2023) · cites this paper as [47]
The Introduction says metabolism plays a significant role in transcription, and the section on yeast metabolic cycles links products of glucose metabolism, especially acetyl-CoA, to histone acetylation and gene transcription. This supports a connection between glucose metabolism and transcription, but does not establish that glucose itself is a key molecule in transcriptional processes. (LLM, conf=0.82)
Experimental — accuracy not yet measuredMetabolic intermediates of the TCA cycle affect epigenetic control of gene expression by regulating histone and DNA modifications.
“metabolic intermediates of the TCA cycle affect epigenetic-mediated control of gene expression through regulating the modification of histones and DNA 137,138”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 95 · Cited by 699
- Authors
- Lu, C., & Thompson, C. B.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Thompson, Craig B.
- ORCID
- Thompson, Craig B.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 16
- Issue
- 1
- Pages
- 9-17
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3392647
- OpenAlex
- W2147494386
- Cited by
- 699
- References
- 95
- Citations by year
- 2026: 52 · 2025: 42 · 2024: 33 · 2023: 47 · 2022: 68 · 2021: 46 · 2020: 62 · 2019: 53 · 2018: 54 · 2017: 46 · 2016: 54 · 2015: 57 · 2014: 51 · 2013: 27 · 2012: 4
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Agios Pharmaceuticals
- National Institutes of Health
- National Cancer Institute (P01CA104838, R01CA105463)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromatin remodeling, chromatin organization, DNA transcription, cytoplasmic signaling, epigenetic modifications, cancer, growth factor signaling, hormone signaling, yeast, mammalian cells
- MeSH terms
- Animals, Circadian Rhythm, Histones, Humans, Neoplasms, Protein Processing, Post-Translational, Saccharomyces cerevisiae, DNA Methylation, Feedback, Physiological, Chromatin Assembly and Disassembly, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
