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Linking Glycogen and Senescence in Cancer Cells
Open accessAbstract
Glycogen metabolism operates as an alternative energy source, enabling cell growth under conditions of metabolic stress. Favaro et al. (2012) now demonstrate that in hypoxic cancer cells, depletion of liver glycogen phosphorylase causes glycogen accumulation, leading to oxidative stress, induction of senescence, and impaired tumor growth in vivo.
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Secondary C3 exhibited upregulation of inflammatory/SASP-associated genes (CXCL8, CSF2, and BMP2) and ECM glycoproteins (LAMA4).
“In contrast, secondary C3 exhibited upregulation of inflammatory/SASP‐associated genes (CXCL8, CSF2, and BMP2) and ECM glycoproteins (LAMA4) (Figure 4A) (Ros and Schulze 2012).”
From Transcriptional Profiling at Single-Cell Resolution Reveals Diversity and Regulatory Networks of Primary and Secondary Senescent Cells (2026) · cites this paper as Ros and Schulze 2012
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Research works printed but not linked: 10
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- Brahimi-Horn, 2011, Curr. Opin. Genet. Dev., 21, 67, 10.1016/j.gde.2010.10.006 · DOI
- Camus, 2012, Oncogene, 31, 4333, 10.1038/onc.2011.594 · DOI
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- Jones, 2005, Int. J. Radiat. Biol., 81, 445, 10.1080/09553000500168549 · DOI
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Lane, A. N., Higashi, R. M., & Fan, T. W.-M. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2019.10.007 · Cited by 91
Structural basis for the recruitment of glycogen synthase by glycogenin
Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402926111 · Cited by 57
Jang, D., Shim, E., Shin, J., Kim, S., Ciotlos, S., Kim, H. J., Gil, T., Kim, Y., & Jeon, O. H. (2026) · Aging Cell · doi:10.1111/acel.70540 · Cited by 2
“In contrast, secondary C3 exhibited upregulation of inflammatory/SASP-associated genes ( CXCL8 , CSF2 , and BMP2 ) and ECM glycoproteins ( LAMA4 ) (Figure 4A) (Ros and Schulze 2012).”
Metadata
- Authors
- Ros, S., & Schulze, A.
- Affiliations
- Cancer Research UK (GB)
- Corresponding author
- Schulze, Almut
- ORCID
- Schulze, Almut
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 16
- Issue
- 6
- Pages
- 687-688
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2088021691
- Cited by
- 31
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Glycogen Storage Diseases and Myoclonus
- Keywords
- glycogen metabolism, cellular senescence, cancer cells, hypoxia, glycogen phosphorylase, glycogen accumulation, oxidative stress, tumor growth, metabolic stress
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