The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion
Open accessAbstract
Summary Early in the pathogenesis of Type 2 diabetes mellitus (T2DM), dysregulated glucagon secretion from pancreatic α-cells occurs prior to impaired glucose stimulated insulin secretion (GSIS) from β-cells. However, whether hyperglucagonemia is causally linked to β-cell dysfunction remains unclear. Here we show that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of the neuropeptide kisspeptin1, which acts on β-cells to suppress GSIS. Synthetic kisspeptin suppresses GSIS in vivo in mice and from isolated islets in a kisspeptin1 receptor-dependent manner. Kisspeptin1 is increased in livers and in serum from humans with T2DM and from mouse models of diabetes mellitus. Importantly, liver Kiss1 knockdown in hyperglucagonemic, glucose intolerant high fat diet fed and Leprdb/db mice augments GSIS and improves glucose tolerance. These observations indicate a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggest in T2DM a sequential link between hyperglucagonemia via hepatic kisspeptin1 to impaired insulin secretion.
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Cites
The biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
The role of dysregulated glucagon secretion in type 2 diabetes
D'Alessio, D. (2011) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01449.x · Cited by 238
Cyclic AMP and Aclrenergic Receptor Control of Rat Liver Glycogen Metabolism
SHERLINE, P., LYNCH, A., & GLINSMANN, W. H. (1972) · Endocrinology · doi:10.1210/endo-91-3-680 · Cited by 209
Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states
El Ouaamari, A., Kawamori, D., Dirice, E., Liew, C. W., Shadrach, J. L., Hu, J., Katsuta, H., Hollister-Lock, J., Qian, W.-J., Wagers, A. J., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.007 · Cited by 136
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Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
SGLT2 Inhibitors May Predispose to Ketoacidosis
Taylor, S. I., Blau, J. E., & Rother, K. I. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1884 · Cited by 560
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
Napso, T., Yong, H. E. J., Lopez-Tello, J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01091 · Cited by 470
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419
Henderson, S. J., Konkar, A., Hornigold, D. C., Trevaskis, J. L., Jackson, R., Fritsch Fredin, M., Jansson‐Löfmark, R., Naylor, J., Rossi, A., Bednarek, M. A., et al. (2016) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12735 · Cited by 240
Metadata
- Authors
- Song, W.-J., Mondal, P., Wolfe, A., Alonso, L. C., Stamateris, R., Ong, B. W. T., Lim, O. C., Yang, K. S., Radovick, S., Novaira, H. J., Farber, E. A., Farber, C. R., Turner, S. D., & Hussain, M. A.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 19
- Issue
- 4
- Pages
- 667-681
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2004507900
- Cited by
- 211
- References
- 4
- FWCI
- 17.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Song, W.-J., Mondal, P., Wolfe, A., Alonso, L. C., Stamateris, R., Ong, B. W. T., Lim, O. C., Yang, K. S., Radovick, S., Novaira, H. J., Farber, E. A., Farber, C. R., Turner, S. D., & Hussain, M. A. (2014). Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion. Cell Metabolism. https://doi.org/10.1016/j.cmet.2014.03.005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
