The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy
Open accessAbstract
Diabetes is characterized by ‘glucotoxic’ loss of pancreatic β-cell function and insulin content, but underlying mechanisms remain unclear. A mouse model of insulin-secretory deficiency induced by β-cell inexcitability (KATP gain-of-function) demonstrates development of diabetes and reiterates the features of human neonatal diabetes. In the diabetic state, β-cells lose their mature identity and dedifferentiate to neurogenin3-positive and insulin-negative cells. Lineage-tracing experiments show that dedifferentiated cells can subsequently re-differentiate to mature neurogenin3-negative, insulin-positive, β-cells after lowering of blood glucose by insulin therapy. We demonstrate here that β-cell dedifferentiation, rather than apoptosis, is the main mechanism of loss of insulin-positive cells, and re-differentiation accounts for restoration of insulin content and antidiabetic-drug responsivity in these animals. These results may help explain gradual decrease in β-cell mass in long-standing diabetes, and recovery of β-cell function and drug responsivity in type-2 diabetic patients following insulin therapy, and suggest an approach to rescuing ‘exhausted’ β-cells in diabetes.
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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
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Islet cell failure in type 2 diabetes
Prentki, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29103 · Cited by 1,690
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Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes
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Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
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Cited by
Animal models of obesity and diabetes mellitus
Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., et al. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.161 · Cited by 832
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
Chen, C., Cohrs, C. M., Stertmann, J., Bozsak, R., & Speier, S. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.019 · Cited by 489
Taylor, R., Al-Mrabeh, A., Zhyzhneuskaya, S., Peters, C., Barnes, A. C., Aribisala, B. S., Hollingsworth, K. G., Mathers, J. C., Sattar, N., & Lean, M. E. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.003 · Cited by 450
Single-Cell Transcriptomics of the Human Endocrine Pancreas
Wang, Y. J., Schug, J., Won, K.-J., Liu, C., Naji, A., Avrahami, D., Golson, M. L., & Kaestner, K. H. (2016) · Diabetes · doi:10.2337/db16-0405 · Cited by 432
Metadata
- Authors
- Wang, Z., York, N. W., Nichols, C. G., & Remedi, M. S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 19
- Issue
- 5
- Pages
- 872-882
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2046438754
- Cited by
- 406
- References
- 60
- FWCI
- 34.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, Z., York, N. W., Nichols, C. G., & Remedi, M. S. (2014). Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy. Cell Metabolism. https://doi.org/10.1016/j.cmet.2014.03.010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
