Microbial modulation of insulin sensitivity
Open accessAbstract
The gut microbiota has emerged as an integral factor that impacts host metabolism and has been suggested to play a vital role in metabolic diseases such as obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. In humans, cross-sectional studies have identified microbiota profiles associated with metabolic diseases, whereas causation mainly has been demonstrated in animal models. Recent studies involving microbiota-based interventions in humans, or transfer of disease-associated microbiota into germ-free mice, underscore that an altered microbiota may directly modulate host metabolism in humans. However, it will be essential to determine whether an altered gut microbiota precedes development of insulin resistance and diabetes and to identify the underlying molecular mechanisms. Increased mechanistic insights of how the microbiota modulates metabolic disease in humans may pave the way for identification of innovative microbiota-based diagnostics and/or therapeutics.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Microbiota-derived LPS has been suggested to traverse the mucosal barrier on chylomicrons.
“Second, microbiota-derived LPS has been suggested to traverse the mucosal barrier of the intestine on chylomicrons, lipoprotein complexes that transport long-chain fatty acids from the gut lumen to the lymph and blood (Ghoshal et al., 2009; Khan et al., 2014; Sonnenburg and Bäckhed, 2016).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Khan et al., 2014
The gut microbiome is implicated directly in the development of type 2 diabetes and cardiovascular disease.
“In addition to obesity, the gut microbiome has also been implicated directly in the development of the two primary complications of Metabolic Syndrome, type 2 diabetes (T2D) and cardiovascular disease (Fändriks, 2016; Jonsson and Bäckhed, 2017; Khan et al., 2014).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Khan et al., 2014
The citation lists haven’t been fetched yet
References 80 · Cited by 260
- Authors
- Khan, M. T., Nieuwdorp, M., & Bäckhed, F.
- Affiliations
- University of Gothenburg (SE)
- University of Copenhagen (DK)
- Corresponding author
- Bäckhed, Fredrik
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 20
- Issue
- 5
- Pages
- 753-760
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1991518996
- Cited by
- 260
- References
- 80
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 30 · 2023: 16 · 2022: 24 · 2021: 25 · 2020: 39 · 2019: 22 · 2018: 15 · 2017: 23 · 2016: 23 · 2015: 25
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- IngaBritt och Arne Lundbergs Forskningsstiftelse
- European Research Council (615362 - METABASE)
- Knut och Alice Wallenbergs Stiftelse
- Stiftelsen för Strategisk Forskning
- Vetenskapsrådet
- AFA Försäkring
- Diabetesförbundet
- Novo Nordisk Fonden
- Hjärt-Lungfonden
- Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, insulin sensitivity, insulin resistance, type 2 diabetes, obesity, cardiovascular disease, metabolic disorders, microbiota-targeted interventions, germ-free mice, host metabolism, microbiota-based therapy
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Gastrointestinal Tract, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
