The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride
Open accessAbstract
Dietary potassium deficiency, common in modern diets, raises blood pressure and enhances salt sensitivity. Potassium homeostasis requires a molecular switch in the distal convoluted tubule (DCT), which fails in familial hyperkalemic hypertension (pseudohypoaldosteronism type 2), activating the thiazide-sensitive NaCl cotransporter, NCC. Here, we show that dietary potassium deficiency activates NCC, even in the setting of high salt intake, thereby causing sodium retention and a rise in blood pressure. The effect is dependent on plasma potassium, which modulates DCT cell membrane voltage and, in turn, intracellular chloride. Low intracellular chloride stimulates WNK kinases to activate NCC, limiting potassium losses, even at the expense of increased blood pressure. These data show that DCT cells, like adrenal cells, sense potassium via membrane voltage. In the DCT, hyperpolarization activates NCC via WNK kinases, whereas in the adrenal gland, it inhibits aldosterone secretion. These effects work in concert to maintain potassium homeostasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, WNK1 interacts with chloride ions (Cl−) to alter its conformation, facilitating the capture of SGK1 (Piala et al., 2014; Terker et al., 2015). This conformational change promotes the interaction between Mammalian Target of Rapamycin Complex 2 (mTORC2) and SGK1 and enhances the phosphorylation of SGK1 while simultaneously inhibiting the kinase activity of WNK1.”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Terker et al., 2015
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sacks, F. M., Svetkey, L. P., Vollmer, W. M., Appel, L. J., Bray, G. A., Harsha, D., Obarzanek, E., Conlin, P. R., Miller, E. R., Simons-Morton, D. G., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440101 · Cited by 5,638
Identification and proteomic profiling of exosomes in human urine
Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162
K + Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension
Choi, M., Scholl, U. I., Yue, P., Björklund, P., Zhao, B., Nelson-Williams, C. J., Ji, W., Cho, Y., Patel, A. P., Men, C. J., et al. (2011) · Science · doi:10.1126/science.1198785 · Cited by 999
Self-citationUrinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events
O'Donnell, M., Mente, A., Rangarajan, S., McQueen, M. J., Wang, X., Liu, L., Yan, H., Lee, S. F., Mony, P., Devanath, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311889 · Cited by 886 · cited 1×
“Recently, in two studies of individuals from around the world, low K+ (LK) intake was strongly associated with both higher blood pressure C and cardiovascular death (Mente et al., 2014; O’Donnell et al., 2014).”
Association of Urinary Sodium and Potassium Excretion with Blood Pressure
Mente, A., O'Donnell, M. J., Rangarajan, S., McQueen, M. J., Poirier, P., Wielgosz, A., Morrison, H., Li, W., Wang, X., Di, C., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311989 · Cited by 858
Sodium and Potassium in the Pathogenesis of Hypertension
Adrogué, H. J., & Madias, N. E. (2007) · New England Journal of Medicine · doi:10.1056/nejmra064486 · Cited by 758
Vitari, A. C., Deák, M., MORRICE, N. A., & Alessi, D. R. (2005) · Biochemical Journal · doi:10.1042/bj20051180 · Cited by 503
Chloride sensing by WNK1 involves inhibition of autophosphorylation
Piala, A. T., Moon, T. M., Akella, R., He, H., Cobb, M. H., & Goldsmith, E. J. (2014) · Science Signaling · doi:10.1126/scisignal.2005050 · Cited by 418
Hoorn, E. J., Walsh, S. B., McCormick, J. A., Fürstenberg, A., Yang, C., Roeschel, T., Paliege, A., Howie, A. J., Conley, J., Bachmann, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2497 · Cited by 388
Self-citationSørensen, M. V., Großmann, S., Roesinger, M., Gresko, N., Todkar, A., Barmettler, G., Ziegler, U., Odermatt, A., Loffing‐Cueni, D., & Loffing, J. (2013) · Kidney International · doi:10.1038/ki.2013.14 · Cited by 360
Cited by
Sorted by citations
Clase, C. M., Carrero, J.-J., Ellison, D. H., Grams, M. E., Hemmelgarn, B. R., Jardine, M. J., Kovesdy, C. P., Kline, G. A., Lindner, G., Obrador, G. T., et al. (2020) · Kidney International · doi:10.1016/j.kint.2019.09.018 · Cited by 498
Self-citationDiuretic Therapy for Patients With Heart Failure
Felker, G. M., Ellison, D. H., Müllens, W., Cox, Z. L., & Testani, J. M. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.059 · Cited by 460
Self-citationDiuretic Treatment in Heart Failure
Ellison, D. H., & Felker, G. M. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1703100 · Cited by 415
Self-citationLifestyle interventions for the prevention and treatment of hypertension
Valenzuela, P. L., Carrera‐Bastos, P., Gálvez, B. G., Ruiz‐Hurtado, G., Ordovás, J. M., Ruilope, L. M., & Lucía, A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00437-9 · Cited by 400
Sexual dimorphic pattern of renal transporters and electrolyte homeostasis
Veiras, L. C., Girardi, A. C. C., Curry, J., Pei, L., Ralph, D. L., Tran, A., Castelo-Branco, R. C., Pastor-Soler, N., Arranz, C. T., Yu, A. S. L., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017030295 · Cited by 316
Physiology and pathophysiology of potassium homeostasis
Palmer, B. F., & Clegg, D. J. (2016) · AJP Advances in Physiology Education · doi:10.1152/advan.00121.2016 · Cited by 286
Terker, A. S., Zhang, C., Erspamer, K. J., Gamba, G., Yang, C., & Ellison, D. H. (2015) · Kidney International · doi:10.1038/ki.2015.289 · Cited by 244
Self-citationWNK Kinase Signaling in Ion Homeostasis and Human Disease
Shekarabi, M., Zhang, J., Khanna, A. R., Ellison, D. H., Delpire, E. J., & Kahle, K. T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.007 · Cited by 247
Self-citationThe Many Faces of Calcineurin Inhibitor Toxicity—What the FK?
Farouk, S. S., & Rein, J. L. (2020) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2019.08.006 · Cited by 236
Potassium homeostasis, oxidative stress, and human disease
Tchounwou, P., & Udensi, U. (2017) · International Journal of Clinical and Experimental Physiology · doi:10.4103/ijcep.ijcep_43_17 · Cited by 221
Clinical Pharmacology in Diuretic Use
Ellison, D. H. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09630818 · Cited by 191
Self-citationRegulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases
Hadchouel, J., Ellison, D. H., & Gamba, G. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105431 · Cited by 183
Self-citationPotassium: From Physiology to Clinical Implications
Zacchia, M., Abategiovanni, M. L., Stratigis, S., & Capasso, G. (2016) · Kidney Diseases · doi:10.1159/000446268 · Cited by 202
Genetic causes of hypomagnesemia, a clinical overview
Viering, D. H. H. M., de Baaij, J. H. F., Walsh, S. B., Kleta, R., & Böckenhauer, D. (2016) · Pediatric Nephrology · doi:10.1007/s00467-016-3416-3 · Cited by 179
Potassium Sensing by Renal Distal Tubules Requires Kir4.1
Cuevas, C. A., Su, X., Wang, M.-X., Terker, A. S., Lin, D., McCormick, J. A., Yang, C., Ellison, D. H., & Wang, W.-H. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016090935 · Cited by 170
Self-citationThe Hypertension Pandemic: An Evolutionary Perspective
Rossier, B. C., Bochud, M., & Devuyst, O. (2017) · Physiology · doi:10.1152/physiol.00026.2016 · Cited by 173
Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis
Hoorn, E. J., Gritter, M., Cuevas, C. A., & Fenton, R. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00044.2018 · Cited by 163
Wang, M.-X., Cuevas, C. A., Su, X., Wu, P., Gao, Z., Lin, D., McCormick, J. A., Yang, C., Wang, W.-H., & Ellison, D. H. (2018) · Kidney International · doi:10.1016/j.kint.2017.10.023 · Cited by 147
Self-citationPotassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits
McDonough, A. A., & Youn, J. H. (2017) · Physiology · doi:10.1152/physiol.00022.2016 · Cited by 146
Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules
Grimm, P. R., Coleman, R. A., Delpire, E. J., & Welling, P. A. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016090948 · Cited by 140
Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport
Terker, A. S., Yarbrough, B., Ferdaus, M. Z., Lazelle, R., Erspamer, K. J., Meermeier, N. P., Park, H. J., McCormick, J. A., Yang, C., & Ellison, D. H. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015070815 · Cited by 139
Self-citationThe ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron
Hennings, J. C., Andrini, O., Picard, N., Paulais, M., Huebner, A. K., López‐Cayuqueo, K. I., Bignon, Y., Keck, M., Cornière, N., Böhm, D., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016010085 · Cited by 115
Insights into Salt Handling and Blood Pressure
Ellison, D. H., & Welling, P. (2021) · New England Journal of Medicine · doi:10.1056/nejmra2030212 · Cited by 116
Self-citationRoles and Regulation of Renal K Channels
Welling, P. A. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105423 · Cited by 109
Pentón, D., Czogalla, J., Wengi, A., Himmerkus, N., Loffing‐Cueni, D., Carrel, M., Rajaram, R. D., Staub, O., Bleich, M., Schweda, F., et al. (2016) · The Journal of Physiology · doi:10.1113/jp272504 · Cited by 109
Royal Jelly: Biological Action and Health Benefits
Oršolić, N., & Jembrek, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116023 · Cited by 117
“I don’t get no respect”: the role of chloride in acute kidney injury
Rein, J. L., & Coca, S. G. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00130.2018 · Cited by 108
WNK4 kinase is a physiological intracellular chloride sensor
Chen, J.-C., Lo, Y., Lin, Y., Lin, S., Huang, C.-L., & Cheng, C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817220116 · Cited by 99
Achieving the Benefits of a High-Potassium, Paleolithic Diet, Without the Toxicity
Palmer, B. F., & Clegg, D. J. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.01.012 · Cited by 97
Essential role of Kir5.1 channels in renal salt handling and blood pressure control
Palygin, O., Levchenko, V., Ilatovskaya, D. V., Pavlov, T. S., Pochynyuk, O. M., Jacob, H. J., Geurts, A. M., Hodges, M. R., & Staruschenko, A. (2017) · JCI Insight · doi:10.1172/jci.insight.92331 · Cited by 98
Liu, Y., Rafferty, T. M., Rhee, S. W., Webber, J. S., Song, L., Ko, B. S., Hoover, R. S., He, B., & Mu, S. (2017) · Nature Communications · doi:10.1038/ncomms14037 · Cited by 95
Potassium Metabolism and Management in Patients with CKD
Yamada, S., & Inaba, M. (2021) · Nutrients · doi:10.3390/nu13061751 · Cited by 101
Effect of diuretics on renal tubular transport of calcium and magnesium
Alexander, R. T., & Dimke, H. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00032.2017 · Cited by 92
New developments in the pathogenesis of obesity-induced hypertension
Kotsis, V., Nilsson, P. M., Grassi, G. M., Mancia, G., Redón, J., Luft, F., Schmieder, R. E., Engeli, S., Stabouli, S., Antza, C., et al. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000645 · Cited by 91
Salt-sensitive hypertension: mechanisms and effects of dietary and other lifestyle factors
Pilić, L., Pedlar, C. R., & Mavrommatis, Y. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw028 · Cited by 89
Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent
Boyd‐Shiwarski, C. R., Shiwarski, D. J., Roy, A., Namboodiri, H., Nkashama, L. J., Xie, J., McClain, K. L., Marciszyn, A. L., Kleyman, T. R., Tan, R. J., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-08-0529 · Cited by 83
Ellison, D. H., Terker, A. S., & Gamba, G. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015070751 · Cited by 76
Self-citationLearning Physiology from Inherited Kidney Disorders
van der Wijst, J., Belge, H., Bindels, R. J. M., & Devuyst, O. (2019) · Physiological Reviews · doi:10.1152/physrev.00008.2018 · Cited by 77
Shoda, W., Nomura, N., Ando, F., Mori, Y., Mori, T., Sohara, E., Rai, T., & Uchida, S. (2016) · Kidney International · doi:10.1016/j.kint.2016.09.001 · Cited by 78
McDonough, A. A., Veiras, L. C., Guevara, C. A., & Ralph, D. L. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00453.2016 · Cited by 75
Potassium acts through mTOR to regulate its own secretion
Sørensen, M. V., Saha, B., Jensen, I. S., Wu, P., Ayasse, N., Gleason, C. E., Svendsen, S. L., Wang, W., & Pearce, D. (2019) · JCI Insight · doi:10.1172/jci.insight.126910 · Cited by 75
Self-citationVasopressin regulation of sodium transport in the distal nephron and collecting duct
Kortenoeven, M. L. A., Pedersen, N. B., Rosenbæk, L. L., & Fenton, R. A. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00093.2015 · Cited by 73
WNK Kinases in Development and Disease
Rodan, A. R., & Jenny, A. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.08.004 · Cited by 70
Gritter, M., Rotmans, J. I., & Hoorn, E. J. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11209 · Cited by 73
WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia
Thomson, M. N., Cuevas, C. A., Bewarder, T. M., Dittmayer, C., Miller, L. N., Si, J., Cornelius, R. J., Su, X., Yang, C., McCormick, J. A., et al. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00232.2019 · Cited by 70
Self-citationIshizawa, K., Wang, Q., Li, J., Yamazaki, O., Tamura, Y., Fujigaki, Y., Uchida, S., Lifton, R. P., & Shibata, S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817281116 · Cited by 69
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4
Castañeda‐Bueno, M., Arroyo, J. P., Zhang, J., Puthumana, J., Yarborough, O. H., Shibata, S., Rojas‐Vega, L., Gamba, G., Rinehart, J., & Lifton, R. P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620315114 · Cited by 65
Crislip, G. R., Douma, L. G., Masten, S., Cheng, K., Lynch, I. J., Johnston, J. G., Barral, D., Glasford, K., Holzworth, M. R., Verlander, J. W., et al. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00014.2020 · Cited by 67
The Molecular Genetics of Gordon Syndrome
Mabillard, H. R., & Sayer, J. A. (2019) · Genes · doi:10.3390/genes10120986 · Cited by 68
Sodium Transporters in Human Health and Disease
Gagnon, K. B., & Delpire, E. J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.588664 · Cited by 72
Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action
Roy, A., Al‐Qusairi, L., Donnelly, B. F., Ronzaud, C., Marciszyn, A. L., Gong, F., Chang, Y. P. C., Butterworth, M. B., Pastor‐Soler, N. M., Hallows, K. R., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci75245 · Cited by 65
Wolley, M. J., Wu, A., Xu, S., Gordon, R. D., Fenton, R. A., & Stowasser, M. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015111221 · Cited by 65
Siew, K., Nestler, K. A., Nelson, C., D’Ambrosio, V., Zhong, C., Li, Z., Grillo, A., Wan, E. R., Patel, V., Overbey, E. G., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49212-1 · Cited by 66
Deletion of claudin-10 rescues claudin-16–deficient mice from hypomagnesemia and hypercalciuria
Breiderhoff, T., Himmerkus, N., Drewell, H., Plain, A., Günzel, D., Mutig, K., Willnow, T. E., Müller, D., & Bleich, M. (2017) · Kidney International · doi:10.1016/j.kint.2017.08.029 · Cited by 64
Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K+excretion
Su, X., Ellison, D. H., & Wang, W.-H. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00412.2018 · Cited by 64
Self-citationGitelman-Like Syndrome Caused by Pathogenic Variants in mtDNA
Viering, D. H. H. M., Schlingmann, K. P., Hureaux, M., Nijenhuis, T., Mallett, A. J., Chan, M., van Beek, A. P., van Eerde, A. M., Coulibaly, J.-M., Vallet, M., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021050596 · Cited by 63
The Development of Novel Drug Treatments for Stroke Patients: A Review
Frank, D., Zlotnik, A. A., Boyko, M., & Gruenbaum, B. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105796 · Cited by 63
Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC
Argaiz, E. R., Chávez‐Canales, M., Ostrosky-Frid, M., Gama, A. R., Vázquez, N. H., González-Rodríguez, X., Garcı́a-Valdés, J., Hadchouel, J., Ellison, D. H., & Gamba, G. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00145.2018 · Cited by 61
Self-citationCl− as a bona fide signaling ion
Lüscher, B. P., Vachel, L., Ohana, E., & Muallem, S. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00354.2019 · Cited by 63
Potassium homeostasis: sensors, mediators, and targets
McDonough, A. A., & Fenton, R. A. (2022) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02718-3 · Cited by 61
Pearce, D., Manis, A. D., Nesterov, V., & Korbmacher, C. (2022) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02732-5 · Cited by 61
A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis
López‐Cayuqueo, K. I., Chávez‐Canales, M., Pillot, A., Houillier, P., Jayat, M., Baraka-Vidot, J., Trepiccione, F., Baudrie, V., Büsst, C., Soukaseum, C., et al. (2018) · Kidney International · doi:10.1016/j.kint.2018.05.001 · Cited by 60
Sinning, A., Radionov, N., Trepiccione, F., López‐Cayuqueo, K. I., Jayat, M., Baron, S., Cornière, N., Alexander, R. T., Hadchouel, J., Eladari, D., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015070734 · Cited by 59
Cheng, L., Poulsen, S. B., Wu, Q., Esteva‐Font, C., Olesen, E. T. B., Peng, L., Olde, B., Leeb-Lundberg, L. M. F., Pisitkun, T., Rieg, T., et al. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018101025 · Cited by 59
Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension
Azlan, N. F. M., Koeners, M. P., & Zhang, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.09.009 · Cited by 58
Pathophysiology and genetics of salt-sensitive hypertension
Maaliki, D. S., Itani, M. M., & Itani, H. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1001434 · Cited by 61
Advances in pathogenesis and treatment of essential hypertension
Ma, J., & Chen, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1003852 · Cited by 77
Ferdaus, M. Z., Barber, K. W., López‐Cayuqueo, K. I., Terker, A. S., Argaiz, E. R., Gassaway, B. M., Chambrey, R., Gamba, G., Rinehart, J., & McCormick, J. A. (2016) · The Journal of Physiology · doi:10.1113/jp272311 · Cited by 58
Self-citationIshizawa, K., Xu, N., Loffing, J., Lifton, R. P., Fujita, T., Uchida, S., & Shibata, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.127 · Cited by 58
Shibata, S. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0669 · Cited by 63
Molecular Crowding: Physiologic Sensing and Control
Subramanya, A. R., & Boyd‐Shiwarski, C. R. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-025920 · Cited by 57
The mineralocorticoid receptor (MR) regulates ENaC but not NCC in mice with random MR deletion
Czogalla, J., Vohra, T., Pentón, D., Kirschmann, M., Craigie, E., & Loffing, J. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1798-5 · Cited by 57
Hypokalemia and Pendrin Induction by Aldosterone
Xu, N., Hirohama, D., Ishizawa, K., Chang, W., Shimosawa, T., Fujita, T., Uchida, S., & Shibata, S. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08519 · Cited by 56
Beneficial Effects of High Potassium
Staruschenko, A. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.10267 · Cited by 65
Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling
Saritas, T., Puelles, V. G., Su, X., McCormick, J. A., Welling, P. A., & Ellison, D. H. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.021 · Cited by 61
Self-citationMutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects
Ferdaus, M. Z., Miller, L. N., Agbor, L. N., Saritas, T., Singer, J. D., Sigmund, C. D., & McCormick, J. A. (2017) · JCI Insight · doi:10.1172/jci.insight.96700 · Cited by 56
Self-citationShould we eat more potassium to better control blood pressure in hypertension?
Burnier, M. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx340 · Cited by 59
Murillo‐de‐Ozores, A. R., Chávez‐Canales, M., Heros, P. D. L., Gamba, G., & Castañeda‐Bueno, M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.585907 · Cited by 56
Distal convoluted tubule Cl−concentration is modulated via K+channels and transporters
Su, X., Klett, N. J., Sharma, A., Allen, C. N., Wang, W.-H., Yang, C., & Ellison, D. H. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00284.2020 · Cited by 54
Self-citationDietary potassium and the kidney: lifesaving physiology
Wei, K., Gritter, M., Vogt, L., de Borst, M. H., Rotmans, J. I., & Hoorn, E. J. (2020) · Clinical Kidney Journal · doi:10.1093/ckj/sfaa157 · Cited by 57
Magnesium reabsorption in the kidney
de Baaij, J. H. F. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00298.2022 · Cited by 53
Veiras, L. C., Han, J., Ralph, D. L., & McDonough, A. A. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07389 · Cited by 53
The WNK signaling pathway and salt-sensitive hypertension
Furusho, T., Uchida, S., & Sohara, E. (2020) · Hypertension Research · doi:10.1038/s41440-020-0437-x · Cited by 55
Potassium homeostasis – Physiology and pharmacology in a clinical context
Kettritz, R., & Loffing, J. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108489 · Cited by 54
Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension
Lazelle, R., McCully, B. H., Terker, A. S., Himmerkus, N., Blankenstein, K. I., Mutig, K., Bleich, M., Bachmann, S., Yang, C., & Ellison, D. H. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015040466 · Cited by 51
Self-citationRodan, A. R. (2016) · Pediatric Nephrology · doi:10.1007/s00467-016-3411-8 · Cited by 53
The renal TRPV4 channel is essential for adaptation to increased dietary potassium
Mamenko, M., Boukelmoune, N., Tomilin, V. N., Zaika, O., Jensen, V. B., O’Neil, R. G., & Pochynyuk, O. M. (2017) · Kidney International · doi:10.1016/j.kint.2016.12.010 · Cited by 51
Wu, P., Gao, Z., Zhang, D., Su, X., Wang, W., & Lin, D. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019010025 · Cited by 51
Self-citationFurusho, T., Sohara, E., Mandai, S., Kikuchi, H., Takahashi, N., Fujimaru, T., Hashimoto, H., Arai, Y., Ando, F., Zeniya, M., et al. (2020) · Kidney International · doi:10.1016/j.kint.2019.11.021 · Cited by 50
Hirohama, D., Nishimoto, M., Ayuzawa, N., Kawarazaki, W., Fujii, W., Oba, S., Shibata, S., Marumo, T., & Fujita, T. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17263 · Cited by 51
Hypokalemia and the Prevalence of Primary Aldosteronism
Gruber, S., & Beuschlein, F. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1134-4980 · Cited by 52
A mathematical model of the rat kidney: K + -induced natriuresis
Weinstein, A. M. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00536.2016 · Cited by 49
Self-citationEffects of extreme potassium stress on blood pressure and renal tubular sodium transport
Boyd‐Shiwarski, C. R., Weaver, C. J., Beacham, R. T., Shiwarski, D. J., Connolly, K. A., Nkashama, L. J., Mutchler, S. M., Griffiths, S. E., Knoell, S. A., Sebastiani, R. S., et al. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00527.2019 · Cited by 48
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases
Bazúa‐Valenti, S., & Gamba, G. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00065.2015 · Cited by 46
Effects of a high-sodium/low-potassium diet on renal calcium, magnesium, and phosphate handling
van der Wijst, J., Tutakhel, O. A. Z., Bos, C., Danser, A. H. J., Hoorn, E. J., Hoenderop, J. G. J., & Bindels, R. J. M. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00379.2017 · Cited by 49
An Integrated View of Potassium Homeostasis
Hoorn, E. J., Loffing, J., & Ellison, D. H. (2015) · New England Journal of Medicine · doi:10.1056/nejmc1509656 · Cited by 48
Self-citationPhysiological role of SLC12 family members in the kidney
Bazúa‐Valenti, S., Castañeda‐Bueno, M., & Gamba, G. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00071.2016 · Cited by 46
Anand, A., Liu, C.-R., Chou, A., Hsu, W.-H., Ulaganathan, R. K., Lin, Y.-C., Dai, C., Tseng, F., Pan, C., & Chen, Y. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00505 · Cited by 46
Al‐Qusairi, L., Basquin, D., Roy, A., Stifanelli, M., Rajaram, R. D., Debonneville, A., Nita, I., Maillard, M. P., Loffing, J., Subramanya, A. R., et al. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00002.2016 · Cited by 45
Sun, Q., Wu, Y., Jonusaite, S., Pleinis, J. M., Humphreys, J. M., He, H., Schellinger, J. N., Akella, R., Stenesen, D., Krämer, H., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017101091 · Cited by 46
Metadata
- Authors
- Terker, A. S., Zhang, C., McCormick, J. A., Lazelle, R. A., Zhang, C., Meermeier, N. P., Siler, D. A., Park, H. J., Fu, Y., Cohen, D. M., Weinstein, A. M., Wang, W.-H., Yang, C.-L., & Ellison, D. H.
- Affiliations
- Oregon Health & Science University (US)
- New York Medical College (US)
- Corresponding author
- Ellison, David H.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 21
- Issue
- 1
- Pages
- 39-50
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4332769
- OpenAlex
- W1970486445
- Cited by
- 457
- References
- 44
- Citations by year
- 2026: 35 · 2025: 23 · 2024: 38 · 2023: 40 · 2022: 53 · 2021: 38 · 2020: 38 · 2019: 42 · 2018: 41 · 2017: 47 · 2016: 38 · 2015: 24
- FWCI
- 39.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01BX002228)
- National Institute of General Medical Sciences (T32GM071338)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-51496, DK 54983, DK098141, R56DK054983, DK-29857, R01DK029857, R01DK054983, T32DK067864, R01DK051496, R01DK098141)
- National Center for Research Resources (S10RR023432)
- Topics
- Health Sciences › Medicine › Nephrology › Potassium and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- distal convoluted tubule, thiazide-sensitive NaCl cotransporter, NCC, WNK kinases, membrane hyperpolarization, intracellular chloride, potassium homeostasis, blood pressure, salt sensitivity, sodium retention, aldosterone secretion, electrolyte balance
- MeSH terms
- WNK Lysine-Deficient Protein Kinase 1, Kcnj10 Channel, Animals, Blood Pressure, Cell Line, Chlorides, Electrolytes, Humans, Kidney Tubules, Distal, Membrane Potentials, Mice, Inbred BALB C, Mice, Inbred C57BL, Potassium, Pseudohypoaldosteronism, Minor Histocompatibility Antigens, Protein Serine-Threonine Kinases, Potassium, Dietary, Sodium Chloride, Dietary, Mice, Knockout, Potassium Channels, Inwardly Rectifying, Mice, Solute Carrier Family 12, Member 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
