FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

Schlein, Christian, Talukdar, Saswata, Heine, Markus, Fischer, Alexander W., Krott, Lucia M., Nilsson, Stefan K., Brenner, Martin B., Heeren, Joerg +1 more·2016·Cell Metabolism
DOI 10.1016/j.cmet.2016.01.006

Cited by (252)

Items 101–200 of 252

  1. Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery
    Tina B. McKay, James Rhee, Katia M. Colon, Katherine Adelsberger, Isabella Turco, Ariel Mueller, Jason Zhensheng Qu, Oluwaseun Akeju · 2021 · Journal of Cardiothoracic and Vascular Anesthesia
  2. RNA-seq and metabolomic analyses of Akt1-mediated muscle growth reveals regulation of regenerative pathways and changes in the muscle secretome
    Chia‐Ling Wu, Yoshinori Satomi, Kenneth X. Walsh · 2017 · BMC Genomics
  3. Fibroblast growth factor 21 is a hepatokine involved in MASLD progression
    Rocío Gallego‐Durán, Javier Ampuero, Douglas Maya‐Miles, Helena Pastor‐Ramírez, Rocío Montero‐Vallejo, Jesús Rivera‐Esteban, Leticia Álvarez‐Amor, María Jesús Pareja, María Carmen Rico, Raquel Millán et al. · 2024 · United European Gastroenterology Journal
  4. Emerging Structure–Function Paradigm of Endocrine FGFs in Metabolic Diseases
    Yongde Luo, Sheng Ye, Xiaokun Li, Weiqin Lu · 2019 · Trends in Pharmacological Sciences
  5. Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance
    Adriano Maida, Annika Zota, Alexandros Vegiopoulos, Sila Appak‐Baskoy, Hellmut G. Augustin, Mathias F Heikenwälder, Stephan Herzig, Adam J. Rose · 2018 · The Journal of Nutritional Biochemistry
  6. FGF21 Protects Against Hypoxia Injury Through Inducing HSP72 in Cerebral Microvascular Endothelial Cells
    Hao‐Wei Wang, Xin Jiang, Yu Zhang, Jian Wang, Jian Wei Xie, Yongqiang Wang, Yonghua Li · 2019 · Frontiers in Pharmacology
  7. TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality
    Frederike Sass, Christian Schlein, Michelle Y. Jaeckstein, Paul Pertzborn, Michaela Schweizer, Thorsten Schinke, Andrea Ballabio, Ludger Scheja, Jöerg Heeren, Alexander W. Fischer · 2021 · Molecular Metabolism
  8. Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: Systematic review and meta-analysis
    Khalafi, Mousa, Alamdari, Karim Azali, Symonds, Michael E., Nobari, Hadi, Carlos-Vivas, Jorge · 2021 · HORMONES
  9. A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target‐gene expression
    Downing, Laura E., Ferguson, Bradley S., Rodriguez, Kelvin, Ricketts, Marie‐Louise · 2017 · Molecular Nutrition & Food Research
  10. Modulation of energy balance by fibroblast growth factor 21
    Daniel Cuevas Ramos, Carlos Alberto Aguilar-Salinas · 2016 · Hormone Molecular Biology and Clinical Investigation
  11. The Novel GlycoPEGylated FGF21 Analog Pegozafermin Activates Human FGF Receptors and Improves Metabolic and Liver Outcomes in Diabetic Monkeys and Healthy Human Volunteers
    M. Rosenstock, Leo Tseng, Andrew A. Pierce, E. Offman, Chao-Yin Chen, R. Charlton, M. Margalit, Hank Mansbach · 2023 · Journal of Pharmacology and Experimental Therapeutics
  12. Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target
    Ilaria Milani, Michela Codini, Gloria Guarisco, Marianna Chinucci, Chiara Gaita, Frida Leonetti, Danila Capoccia · 2024 · International Journal of Molecular Sciences
  13. The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression
    Makarova En, A. Yu. Kazantseva, Anastasia Dubinina, Tatiana Jakovleva, Natalia Balybina, Konstantin O. Baranov, Н. М. Бажан · 2021 · International Journal of Molecular Sciences
  14. FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk
    AKI T.B. CHAFFIN, Karlton R. Larson, Kuei-Pin Huang, Chih-Ting Wu, Godoroja Nadejda, Yanbin Fang, Devi Jayakrishnan, Karla A. Soto Sauza, Landon C. Sims, Niloufar Mohajerani et al. · 2022 · JCI Insight
  15. Sterol 12α-Hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP-1C Pathway via FGF21 and FGF15
    Preeti Pathak, John Y.L. Chiang · 2019 · Gene Expression
  16. Time‐restricted feeding alleviates cardiac dysfunction induced by simulated microgravity via restoring cardiac FGF21 signaling
    Xin‐Pei Wang, Changyang Xing, Jiaxin Zhang, Jia‐Heng Zhou, Yun‐Chu Li, Hong‐Yan Yang, Pengfei Zhang, Wei Zhang, Yin Huang, Jiangang Long et al. · 2020 · The FASEB Journal
  17. Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21
    Jay W. Porter, Joe L. Rowles, Justin A. Fletcher, Terese M. Zidon, Nathan C. Winn, Leighton McCabe, Young-Min Park, James W. Perfield, John P. Thyfault, R. Scott Rector et al. · 2017 · Journal of Endocrinology
  18. Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)
    Laura E. Downing, Daniel Edgar, Patricia A. Ellison, Marie‐Louise Ricketts · 2017 · Cell Biochemistry and Function
  19. Association of elevated circulating fibroblast growth factor 21 levels with prevalent and incident metabolic syndrome: The Multi-Ethnic Study of Atherosclerosis
    Kwok Leung Ong, Robyn L. McClelland, Matthew Allison, John Kokkinos, Ben J. Wu, Philip J. Barter, Kerry‐Anne Rye · 2018 · Atherosclerosis
  20. High-Level Serum Fibroblast Growth Factor 21 Concentration Is Closely Associated With an Increased Risk of Cardiovascular Diseases: A Systematic Review and Meta-Analysis
    Yucong Zhang, Jinhua Yan, Ni Yang, Zonghao Qian, Hao Nie, Zhen Lu Yang, Dan Yan, Xiuxian Wei, Lei Ruan, Yi Huang et al. · 2021 · Frontiers in Cardiovascular Medicine
  21. Current and Emerging Treatment Options for Hypertriglyceridemia: State-of-the-Art Review
    Jakub Michał Zimodro, Manfredi Rizzo, Ioanna Gouni‐Berthold · 2025 · Pharmaceuticals
  22. Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
    Byong-Keol Min, Chang Joo Oh, Sungmi Park, Ji-Min Lee, Younghoon Go, Bo-Yoon Park, Hyeon‐Ji Kang, Dong Wook Kim, Jeongeun Kim, Eun Kyung Yoo et al. · 2019 · Experimental & Molecular Medicine
  23. The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins
    Alexander W. Fischer, Kirstin Albers, Lucia M. Krott, Britta Hoffzimmer, Markus Heine, Hartwig Schmale, Ludger Scheja, Philip L.S.M. Gordts, Jöerg Heeren · 2018 · Molecular Metabolism
  24. Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model
    Deborah Amos, Carla R. Cook, Nalini Santanam · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  25. Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα
    Philip M. M. Ruppert, Jong‐Gil Park, Xu Xu, Kyu Yeon Hur, Ann–Hwee Lee, Sander Kersten · 2019 · BMC Genomics
  26. A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids
    Leonida Hehl, Kate Townsend Creasy, Cecilia Vitali, Eleonora Scorletti, Katharina Sophie Seeling, Mara Sophie Vell, Miriam Daphne Rendel, Donna Conlon, Marijana Vujković, Inuk Zandvakili et al. · 2024 · Hepatology Communications
  27. Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice
    Longwei Zhao, Huiyan Wang, Jun-Jun Xie, Zilu Chen, Xiaokun Li, Jianlou Niu · 2017 · BMC Biotechnology
  28. Transcriptional Factors of Thermogenic Adipocyte Development and Generation of Brown and Beige Adipocytes From Stem Cells
    Thi-Tuong Van Nguyen, Vuong Van Vu, Phuc Van Pham · 2020 · Stem Cell Reviews and Reports
  29. FGF9 inhibits browning program of white adipocytes and associates with human obesity
    Yingkai Sun, Rui Wang, Shaoqian Zhao, Wen Li, Wen Liu, Lingyun Tang, Zhugang Wang, Weiqing Wang, Ruixin Liu, Guang Ning et al. · 2018 · Journal of Molecular Endocrinology
  30. Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition
    Yoshimi Nakagawa, Yunong Wang, Song‐iee Han, Kanako Okuda, Asayo Oishi, Yuka Yagishita, Kae Kumagai, Hiroshi Ohno, Yoshinori Osaki, Yuhei Mizunoe et al. · 2020 · Cellular and Molecular Gastroenterology and Hepatology
  31. Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine
    Han Fang, Kirsten P. Stone, Laura A. Forney, Desiree Wanders, Thomas W. Gettys · 2021 · Frontiers in Endocrinology
  32. Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis
    Wanrong Guo, Huanyi Cao, Yunfeng Shen, Wuguo Li, Wei J. Wang, Lidan Cheng, Mengyin Cai, Fen Liang Xu · 2024 · Nutrition and Diabetes
  33. Loss of Transcription Factor CREBH Accelerates Diet-Induced Atherosclerosis in Ldlr −/− Mice
    Jong‐Gil Park, Xu Xu, Sungyun Cho, Ann–Hwee Lee · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
  34. Dynamic folding modulation generates FGF21 variant against diabetes
    Lei Zhu, Hongxin Zhao, Juanjuan Liu, Hao Cai, Bo Wu, Zhijun Liu, Shu Zhou, Qingsong Liu, Xiaokun Li, Bin Bao et al. · 2020 · EMBO Reports
  35. Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary‐induced obesity
    Hsin‐Hsueh Shen, Ragin Alex, Lars Bellner, Marco Raffaele, Maria Licari, Luca Vanella, David E. Stec, Nader G. Abraham · 2020 · Journal of Food Biochemistry
  36. The autocrine role of FGF21 in cultured adipocytes
    Sarah Justesen, Kirsten V. Haugegaard, Jacob Bo Hansen, Harald Severin Hansen, Birgitte Andersen · 2020 · Biochemical Journal
  37. The Cardiohepatic Axis in Metabolic Disease
    Andrew N. Hakeem, Jop H. van Berlo, Xavier S. Revelo · 2025 · JACC Basic to Translational Science
  38. PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles
    Alexander W. Fischer, Kirstin Albers, Christian Schlein, Frederike Sass, Lucia M. Krott, Hartwig Schmale, Philip L.S.M. Gordts, Ludger Scheja, Jöerg Heeren · 2019 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  39. Effects of Exercise Intervention on Mitochondrial Stress Biomarkers in Metabolic Syndrome Patients: A Randomized Controlled Trial
    Jae Seung Chang, Jun Namkung · 2021 · International Journal of Environmental Research and Public Health
  40. Curcumin improves metabolic response and increases expression of thermogenesis-associated markers in adipose tissue of male offspring from obese dams
    Augusto Cândido Correia Santos, Lílian Betânia Reis Amaro, Antônio Henrique Batista Jorge, Sarah de Farias Lelis, Deborah de Farias Lelis, André Luiz Sena Guimarães, Sérgio Henrique Sousa Santos, João Marcus Oliveira Andrade · 2022 · Molecular and Cellular Endocrinology
  41. Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy
    Ibrahim Sultan, Markus O Ramste, Pim Peletier, Karthik Amudhala Hemanthakumar, Deepak Prabhu Ramanujam, Annakaisa Tirronen, Ylva von Wright, Salli Antila, Pipsa Saharinen, Lauri Eklund et al. · 2024 · Circulation Research
  42. The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk
    M. Pilar Valdecantos, Laura Ruiz, Cintia Folgueira, Patricia Rada, Beatriz Gómez‐Santos, Maite Solas, Ana B. Hitos, Joss Field, Vera Francisco, Carmen Escalona-Garrido et al. · 2024 · Nature Communications
  43. Hepatoprotective effects of the long-acting fibroblast growth factor 21 analog PF-05231023 in the GAN diet-induced obese and biopsy-confirmed mouse model of nonalcoholic steatohepatitis
    Malte Hasle Nielsen, Matthew Paul Gillum, Niels Vrang, Jacob Jelsing, Henrik H. Hansen, Michael Feigh, Denise Oró · 2023 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  44. Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster
    Jo Edward Lewis, Chloé Monnier, Hayley J. Marshall, Maxine J Fowler, Rebecca Green, Scott Cooper, Aristeidis Chiotellis, Jeni Luckett, Alan Christopher Perkins, Tamer Coşkun et al. · 2019 · Molecular Metabolism
  45. Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice
    Alexander W. Fischer, Janina Ruth Behrens, Frederike Sass, Christian Schlein, Markus Heine, Paul Pertzborn, Ludger Scheja, Jöerg Heeren · 2020 · Journal of Lipid Research
  46. Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis
    Parimal Pande, Xiao‐bo Zhong, Warren W. Ku · 2020 · Drug Metabolism and Disposition
  47. The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner
    Subramanya Srikantan, Yilun Deng, Zi-Ming Cheng, Anqi Luo, Yuejuan Qin, Qing Gao, Glaiza-Mae Sande-Docor, Sifan Tao, Xingyu Zhang, Nathan Harper et al. · 2019 · Nature Communications
  48. Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range
    Lars Lühl, К. А. Андрианов, Hanna Dierks, Andreas Haidl, Aurélie Dehlinger, Markus Heine, Jörg Heeren, Thomas Nisius, Thomas Wilhein, Birgit Kanngießer · 2019 · Journal of Synchrotron Radiation
  49. Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis
    Ye Cao, Masaya Araki, Yoshimi Nakagawa, Luisa Deisen, Anne‐Marie Lundsgaard, Josephine M. Kanta, Stephanie Kjærulff Holm, Kornelia Johann, Jens Christian Jacobsen, Markus Jähnert et al. · 2024 · Molecular Metabolism
  50. The role of novel adipokines and adipose-derived extracellular vesicles (ADEVs): Connections and interactions in liver diseases
    Lijun Xie, Huiying Wang, Jinying Hu, Zhuoying Liu, Fang Hu · 2024 · Biochemical Pharmacology
  51. FGF21 decreases food intake and body weight in obese Göttingen minipigs
    Berit Østergaard Christoffersen, Ellen Marie Straarup, Kirsten Lykkegaard, Johannes Josef Fels, Kristian Sass‐Ørum, Xujia Zhang, Kirsten Raun, Birgitte Andersen · 2018 · Diabetes Obesity and Metabolism
  52. Triglyceride-Rich Lipoproteins and Novel Targets for Anti-atherosclerotic Therapy
    Željko Reiner · 2018 · Korean Circulation Journal
  53. GPR120 controls neonatal brown adipose tissue thermogenic induction
    Tania Quesada‐López, Aleix Gavaldà‐Navarro, Samantha Morón‐Ros, Laura Campderrós, Roser Iglesias, Marta Giralt, Francesc Villarroya · 2019 · American Journal of Physiology-Endocrinology and Metabolism
  54. Fibroblast growth factor 21: update on genetics and molecular biology
    Daniel R. Barros, Robert Alexander Hegele · 2024 · Current Opinion in Lipidology
  55. Endoplasmic reticulum stress at the forefront of fatty liver diseases and cancer
    Michael Karin, Ju Youn Kim · 2025 · Pharmacological Reviews
  56. Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression
    Anna Worthmann, Christian Schlein, Jimmy F.P. Berbée, Patrick C.N. Rensen, Jöerg Heeren, Alexander Bartelt · 2019 · Nutrients
  57. Causative and Sanative dynamicity of ChREBP in Hepato-Metabolic disorders
    P. Vineeth Daniel, Prosenjit Mondal · 2020 · European Journal of Cell Biology
  58. The Interrelation Between Hypothyroidism and Non-alcoholic Fatty Liver Disease, a Cross-sectional Study
    Sarah Elshinshawy, Hemmat E. El Haddad, Shereen Abdel Alem, Olfat Gamil Shaker, Randa Salam, Ayman Yosry, Ibrahim Elebrashy · 2023 · Journal of Clinical and Experimental Hepatology
  59. Influence of Adipokines on Metabolic Dysfunction and Aging
    Seongjoon Park, Isao Shimokawa · 2024 · Biomedicines
  60. Implications of thermogenic adipose tissues for metabolic health
    Christian Schlein, Jöerg Heeren · 2016 · Best Practice & Research Clinical Endocrinology & Metabolism
  61. Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21
    Matthias A. Dille, Aleksandra Nikolic, Natalie Wahlers, Pia Fahlbusch, Sylvia Jacob, Sonja Hartwig, Stefan Lehr, Dhiraj G. Kabra, Oleksiy Klymenko, Hadi Al‐Hasani et al. · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  62. Pegozafermin Is a Potential Master Therapeutic Regulator in Metabolic Disorders: A Review
    Nadian Bailey, Stephen J. Peterson, Manish A. Parikh, Kaedrea A. Jackson, William H. Frishman · 2023 · Cardiology in Review
  63. Genetics of Triglyceride-Rich Lipoproteins Guide Identification of Pharmacotherapy for Cardiovascular Risk Reduction
    Aleesha Shaik, Robert S. Rosenson · 2021 · Cardiovascular Drugs and Therapy
  64. Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma
    Nana-Fatima Haruna, Sergejs Berdnikovs, Zhenying Nie · 2024 · Journal of Leukocyte Biology
  65. Oleuropein mitigates non‐alcoholic fatty liver disease (NAFLD) and modulates liver metabolites in high‐fat diet‐induced obese mice via activating PPARα
    Wei Zhou, Zheng Du · 2024 · Journal of the Science of Food and Agriculture
  66. Improvements in Exercise for Alzheimer’s Disease: Highlighting FGF21-Induced Cerebrovascular Protection
    Juan Wang, Xiangyuan Meng, Yang Jialun, Yingzhe Tang, Fanqi Zeng, Yiyang Wang, Zeyu Chen, Dandan Chen, Ruihan Zou, Wenfeng Liu · 2025 · Neurochemical Research
  67. Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing
    Alejandro Fernández, Lorena Mazuecos, Cristina Pintado, Blanca Rubio, Virginia López, Alain J. De Solís, María Rodríguez-Pérez, Antonio Andrés, Nilda Gallardo · 2019 · Nutrients
  68. Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human primates
    Murray, Sara A., Dalbøge, Louise S., Baquero, Karalee, Sanford, Christina A., Misquith, Ayesha, Mercer, Aaron J., Meek, Thomas H., Guldbrandt, Mette, Andersen, Birgitte, Kievit, Paul et al. · 2020 · Scientific Reports
  69. Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs Its Signaling Pathways in Liver and Adipose Tissue in Mice
    Xinhua Liu, Zachary Graham, Lauren Harlow, Jiangping Pan, Daniella Azulai, William A. Bauman, Joshua F. Yarrow, Christopher P. Cardozo · 2021 · Frontiers in Endocrinology
  70. Increased plasma apoM levels impair triglyceride turnover in mice
    Stefan Hajny, Anna Borup, Sara Elsøe, Christina Christoffersen · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  71. Fibroblast Growth Factor 21 Predicts Short-Term Prognosis in Patients With Acute Heart Failure: A Prospective Cohort Study
    Guihai Wu, Shenglin Wu, Jingyi Yan, Shanshan Gao, Jinxiu Zhu, Minghui Yue, Zexin Li, Xuerui Tan · 2022 · Frontiers in Cardiovascular Medicine
  72. The Different Shades of Thermogenic Adipose Tissue
    Yunwen Hu, Yijie Huang, Yangjing Jiang, Lvkan Weng, Zhaohua Cai, Ben He · 2024 · Current Obesity Reports
  73. Brown Adipose Tissue: A Protective Mechanism Against “Preprediabetes”?
    John P. Crandall, Tyler J. Fraum, Richard L. Wahl · 2022 · Journal of Nuclear Medicine
  74. Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
    Ronald Jan Corbee, Dion L. van Everdingen, H.S. Kooistra, Louis C. Penning · 2023 · Frontiers in Veterinary Science
  75. Fibroblast growth factor 21 potentially inhibits microRNA-33 expression to affect macrophage actions
    Yuan Guo, F. Luo, Y. Yi, Danyan Xu · 2016 · Lipids in Health and Disease
  76. Parsing the Potential Neuroendocrine Actions of FGF21 in Primates
    Matthew Paul Gillum · 2018 · Endocrinology
  77. Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source
    Eun Hye Lee, So Young Chun, Jun Nyung Lee, Jae-Wook Chung, Bo Hyun Yoon, Hyun Tae Kim, Tae Gyun Kwon, Yun‐Sok Ha, Bum Soo Kim · 2021 · Journal of Clinical Medicine
  78. Shedding light on FGF21: A potential negative regulator of PCSK9
    Yuan Guo, Qiong Liu, Danyan Xu · 2016 · International Journal of Cardiology
  79. Computational modelling of energy balance in individuals with Metabolic Syndrome
    Yvonne J.W. Wesseling-Rozendaal, Yanan Wang, P.A.J. Hilbers, Natal A. W. van Riel · 2019 · BMC Systems Biology
  80. Association of the 3′UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity
    Alan Joel Ruiz-Padilla, Gerardo Morales-Hernandez, Yeniley Ruíz‐Noa, Ángel Josabad Alonso‐Castro, María-Luisa Lazo-de-la-Vega-Monroy, Mónica del Carmen Preciado‐Puga, Rubén Rangel-Salazar, Lorena del Rocío Ibarra‐Reynoso · 2019 · Journal of Pediatric Endocrinology and Metabolism
  81. Transgenic mice producing the trans 10, cis 12-conjugated linoleic acid present reduced adiposity and increased thermogenesis and fibroblast growth factor 21 (FGF21)
    Yu Rao, Shili Li, Meijuan Li, Baozhu Wang, Yangyang Wang, Lu-Wen Liang, Shuai Yu, Zongping Liu, Sheng Cui, Kemian Gou · 2023 · The Journal of Nutritional Biochemistry
  82. FGF21-protection against fructose-induced lipid accretion and oxidative stress is influenced by maternal nutrition in male progeny
    Elena Fauste, Silvia Rodrigo, Lourdes Rodríguez, Cristina Donis, Antonia Garcı́a, Coral Barbas, Juan J. Álvarez‐Millán, Maria Isabel Panadero, Paola Otero, Carlos Bocos · 2019 · Journal of Functional Foods
  83. Prepregnancy GLP ‐ 1RA use improves maternal lipid metabolism via liver‐secreted FGF21 during pregnancy in HFD ‐fed dams
    Haonan Guo, Yingyu Jing, Yifan Zhang, Lin Song, Wenjing Wu, Jingyue Wang, Mengjun Wang, Xinyi Niu, Mingxi Wang, Xingyan Pan et al. · 2025 · Obesity
  84. Pharmacologic Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Context of Type 2 Diabetes
    Konstantinos Malandris, Konstantinos Charalampidis, Rohit Seth Loomba, Emmanouil Sinakos · 2026 · Current Diabetes Reports
  85. Do Sugar-Sweetened Beverages Increase Fasting FGF21 Irrespective of the Type of Added Sugar? A Secondary Exploratory Analysis of a Randomized Controlled Trial
    Bettina Geidl, Michel Hochuli, Giatgen A. Spinas, Philipp A. Gerber · 2022 · Nutrients
  86. Pulling the trigger: Noncoding RNAs in white adipose tissue browning
    Dehuan Liang, Guoping Li · 2023 · Reviews in Endocrine and Metabolic Disorders
  87. Functions of FGF21 and its role in cardiac hypertrophy
    Lei Chen, Meng Gao, Sang‐Bing Ong, Guohua Gong · 2025 · Journal of Advanced Research
  88. Lysosomal acid lipase promotes endothelial proliferation in cold-activated adipose tissue
    Alexander W. Fischer, Michelle Y. Jaeckstein, Jöerg Heeren · 2021 · Adipocyte
  89. Thermoneutrality or standard temperature: is there an ideal housing temperature to study the antisteatotic effects of green tea in obese mice?
    Victória Silva, Hector Oreliana Fernandes Faria, Celso Pereira Batista Sousa Filho, José Fernando Rinaldi de Alvarenga, Jarlei Fiamoncini, Rosemari Otton · 2023 · The Journal of Nutritional Biochemistry
  90. Research Progress of Fibroblast Growth Factor 21 in Fibrotic Diseases
    Min-Qi Jia, Cha‐Xiang Guan, Jia‐Hao Tao, Yong Zhou · 2022 · Oxidative Medicine and Cellular Longevity
  91. Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women
    Yeli Wang, Woon‐Puay Koh, Jian‐Min Yuan, An Pan · 2017 · Nutrition & Metabolism
  92. Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass
    Yunhui Xu, Yongke Lu · 2022 · Biochemical and Biophysical Research Communications
  93. Trans 10, cis 12-conjugated linoleic acid in low concentration reduces while in high concentration enhances adipocyte metabolism but effectively improves hepatic steatosis of obese mice
    Yu Rao, Shuai Yu, Luwen Liang, Qi Wang, Jiaqi Lu, Baozhu Wang, Kemian Gou · 2024 · The Journal of Nutritional Biochemistry
  94. Endothelin receptor B-deficient mice are protected from high-fat diet-induced metabolic syndrome
    Martina Feger, Leonie Meier, Jörg M. Strotmann, Miriam Hoene, Julia Vogt, A. Wisser, Susanna Hirschle, Marie-Jo Kheim, Berthold Hocher, Cora Weigert et al. · 2023 · Molecular Metabolism
  95. Investigation of the Characteristics of Crimean Congo Hemorrhagic Fever Cases Reported in Afyonkarahisar Province
    Derya Korkmaz, Petek Şarlak Konya, Neşe Demirtürk · 2022 · Turkish Journal of Parasitology
  96. A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics
    Zhiheng Rao, Zhichao Chen, Yuxuan Bao, Zhenzhen Lu, Yuli Tang, Jiamei Zhu, Jianjia Ma, Siyang Dong, Jiawei Shi, Suhui Sheng et al. · 2025 · Signal Transduction and Targeted Therapy
  97. Fibroblast Growth Factor 21: Mechanisms, Therapeutic Potential, and Clinical Translation in Metabolic Dysfunction
    Kaanthi Rama, Vinay Jahagirdar, Arun Jayant Sanyal · 2026 · Drug Design Development and Therapy
  98. Treating metabolic dysfunction‐associated steatohepatitis: The fat‐trimming FGF21 approach
    Xiaokun Li, Zhiheng Rao, Wenhao Hu, Weiqin Lu, Yongde Luo · 2024 · Obesity Reviews
  99. Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside
    Yeping Huang, Bin Liu, Cheng Hu, Yan Lu · 2025 · Protein & Cell
  100. A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging
    Chrysovalantou E. Xirouchaki, Esther García-Domínguez, E. Coughlan, Meagan J. McGrath, Saveen Giri, Shuwei Liang, F. Wiede, Anne Bigot, Junichi Sadoshima, M. Gómez-Cabrera et al. · 2026 · Science Advances