Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

Arda, H. Efsun, Li, Lingyu, Tsai, Jennifer, Torre, Eduardo A., Rosli, Yenny, Peiris, Heshan, Spitale, Robert C., Dai, Chunhua +11 more·2016·Cell Metabolism
DOI 10.1016/j.cmet.2016.04.002

Cited by (222)

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  2. Pancreatic β-Cell Development and Regeneration
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  9. Pancreatic Pseudoislets: An Organoid Archetype for Metabolism Research
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