Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

Luan, Harding H., Medzhitov, Ruslan·2016·Cell Metabolism
DOI 10.1016/j.cmet.2016.08.013

Cited by (129)

Items 101–129 of 129

  1. Itaconate Attenuates Homocysteine-induced Nod-like Receptor Family Protein 3 Inflammasome-mediated Pyroptosis in Hippocampal Neurons: Involvement of Inhibiting Succinate Dehydrogenase Complex Subunit A Level
    Min Huang, Panpan Zhang, Yi-Yun Tang, Min Li, Jiamei Jiang, Xiao-Qing Tang · 2025 · Journal of physiological investigation.
  2. Host–microbe interactions in the lung and the role of immunometabolism
    Sebastián A. Riquelme, Ayesha Zainab Beg, Tania Wong Fok Lung, Alice S. Prince · 2025 · Elsevier eBooks
  3. New Flavors in Immunomodulation
    Jacques Deguine · 2018 · Cell
  4. Immunometabolic remodeling: new perspectives and strategies for liver transplantation
    Longbo Wang, Xiyang Sheng, Gengyuan Shi, Yongzhao Li, Dongdong Wang, Wei Wang, Chen Mi, Siyang Wang, Yongyue Du, 杨含腾 · 2026 · Frontiers in Immunology
  5. 4-Octyl itaconate treatment inhibits mitochondrial dysfunction and ER stress via stimulating SIRT1 expression in vitro and attenuates osteoarthritis process in murine DMM model in vivo
    Ziping Yu, Zhao Zhang, Xuancheng Zhang, Junduo Bao, Hualin Li, Jiapei Yu, Ning Shi, Fulong Nan, Liang Cao, Chenghui Li et al. · 2023 · Journal of Functional Foods
  6. Aroylated phenylenediamine HO53 modulates innate immunity, histone acetylation and metabolism
    Marjorie Laurence Barrier, Iwona T. Myszor, Priyanka Sahariah, Snævar Sigurðsson, Miguel Carmena‐Bargueño, Horacio Pérez‐Sánchez, Gudmundur Hrafn Gudmundsson · 2023 · Molecular Immunology
  7. Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis
    Gareth‐Rhys Jones, Broc Drury, Tobi Alegbe, Monika Krzak, Lizi M. Hegarty, Tim Raine, Adam Bryne, Carl A. Anderson, Gwo‐Tzer Ho, Calum C. Bain · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Predictive Biomarkers of Methotrexate Treatment Response in Patients with Rheumatoid Arthritis: A Systematic Review
    Adla Bakri Hassan, Rowida M. Hamid, Saja H. Alamien, Namaa A. Khalil, Duaij Salman Saif, Mohammed Elfaki, Haitham Jahrami · 2025 · Metabolites
  9. Chemical-mediated alteration of antibiotic susceptibility: mechanisms and potential new targets for antibiotic adjuvant discovery
    Joshua M. E. Adams, Omar M. El-Halfawy · 2026 · Journal of Bacteriology
  10. Role and prognostic value of N6-methyladenosine RNA modification regulators in glycolytic reprogramming during sepsis
    Xia Liu, Yanyu Zhang, Lei Feng, Aruna Xiang, Zhu-Qin Kang, Qi Zhang, Lei Kang · 2026 · Journal of Intensive Care
  11. Itaconate boosts type I IFN response by disrupting cytoprotection
    Theresa Raquel de Oliveira Ramalho, Ricardo T. Gazzinelli · 2025 · Nature Metabolism
  12. Modification of Starch Using Itaconic Anhydride and its Characterizations
    Dita Rengganis, Rachmawati Rachmawati · 2021 · Key engineering materials
  13. Listeria monocytogenes Requires Phosphotransferase Systems to Facilitate Intracellular Growth and Virulence
    Matthew J. Freeman, John‐Demian Sauer · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Discovery of a novel stereospecific β-hydroxyacyl-CoA lyase/thioesterase shared by three metabolic pathways in Mycobacterium tuberculosis
    Hua Wang, Alexander A. Fedorov, E.V. Fedorov, Deborah M. Hunt, Angela Rodgers, Acely Garza-Garcı́a, J.B. Bonanno, Steven C. Almo, Luiz Pedro S. de Carvalho · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  15. The glyoxylate shunt as a target for antibacterial intervention in Pseudomonas aeruginosa
    Alyssa C. McVey · 2019 · Apollo (University of Cambridge)
  16. Metabolic Reprogramming and Infectious Diseases
    Érika Machado de Salles, Bárbara Cristina Pizzolante, Denise Morais da Fonseca · 2021 · Springer eBooks
  17. Faculty Opinions recommendation of An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism.
    Christina L. Stallings, Eric Michael Nehls · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  18. Macrophage internalization creates a multidrug-tolerant fungal persister population, providing a permissive reservoir for the emergence of drug resistance
    Amir A. Arastehfar, Farnaz Daneshnia, Nathaly Cabrera, Suyapa Penalva-Lopez, Jansy Passiflora Sarathy, Matthew Zimmerman, Erika Shor, David S. Perlin · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  19. Engineering thioesterase as a driving force for novel itaconate production via its degradation scheme
    Ryan S. Wang, Siang-Wun Siao, Jessica C. Wang, Patrick Y. Lin, Claire R. Shen · 2024 · Metabolic Engineering Communications
  20. Additional file 10 of Short-term feeding of defatted bovine colostrum mitigates inflammation in the gut via changes in metabolites and microbiota in a chicken animal model
    Ted H. Elsasser, Ma, Bing, Jacques Ravel, S. Kahl, Pawel Gajer, Cross, Alan · 2023 · Figshare
  21. Additional file 5 of Short-term feeding of defatted bovine colostrum mitigates inflammation in the gut via changes in metabolites and microbiota in a chicken animal model
    Ted H. Elsasser, Ma, Bing, Jacques Ravel, S. Kahl, Pawel Gajer, Cross, Alan · 2023 · Figshare
  22. Additional file 9 of Short-term feeding of defatted bovine colostrum mitigates inflammation in the gut via changes in metabolites and microbiota in a chicken animal model
    Ted H. Elsasser, Ma, Bing, Jacques Ravel, S. Kahl, Pawel Gajer, Cross, Alan · 2023 · Figshare
  23. Synthesis and Characterization of Bioactive Oligoitaconates with Amino Acid Functional Groups for Tissue Engineering
    Marta Chrószcz-Porębska, Sylwia Waśkiewicz, Tomasz Gołofit, Agnieszka Gadomska‐Gajadhur · 2025 · International Journal of Molecular Sciences
  24. Dissecting the host transcriptome and microbiota responses to viral hemorrhagic septicemia virus (VHSV) in the turbot (Scophthalmus maximus) intestine: insights from moribund and asymptomatic phenotypes
    Nieves Martínez-López, Antonio J. Figueras, Beatriz Novoa, Patricia Pereiro · 2026 · Fish & Shellfish Immunology
  25. Biochemical characterization and molecular mechanism study of trans-aconitate decarboxylase Tad1
    Yiping Lu, Keke Zhang, Chongyang Wang, Danni Wu, Xuenian Huang, Huifang Xu, Honglei Ma, Xuefeng Lu · 2026 · Enzyme and Microbial Technology
  26. Itaconate and its derivatives in human health and diseases
    Jianyou Gu, Wenying Zhang, Junfeng Zhang, Silue Zeng, Renpei Xia, Lei Cai, Xiaosheng Zhong, Shixiang Guo, Huaizhi Wang, Zhe‐Sheng Chen · 2026 · Signal Transduction and Targeted Therapy
  27. The ACOD1-itaconate axis in anti-neuroinflammation and protection against neurodegenerative diseases
    Dahui Wang, Jensen G Weedor, Natasha M Weah, Stephane Koda, Cleopatra Martricia Quayon, Wei Xing Pan, Yinghua Yu · 2026 · Journal of Alzheimer s Disease
  28. Itaconate as an immunometabolic hub in host–pathogen interactions: Mechanisms, resistance, and therapeutic opportunities
    Wei Zuo, Xinhui Wang, Jiaxiang Sun, Weiqi Guo, Beibei Zhang, Xinyu Wang, Jiangang Hu, Jingjing Qi, Mingxing Tian, Lei Deng et al. · 2026 · Virulence
  29. Powerhouses of lethality: mitochondria in macrophage antimicrobial activity
    Michael J. McFadden, Teresa R. O’Meara, Mary X O’Riordan · 2026 · Infection and Immunity