Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
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Mito-1C-deficient cells have altered dependency on exogenous glycine due to loss of endogenous glycine production by SHMT2.
“Previous studies have shown that mito-1C–deficient cells have altered dependency on exogenous glycine due to the loss of endogenous glycine production by SHMT2 (17).”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [17]
Glycine auxotrophy in mito-1C-deficient cells could be reversed with exogenous cell permeable GSH.
“The glycine auxotrophy in mito-1C–deficient cells could be reversed with the exogenous supply of cell permeable GSH (Fig. 2B and fig. S2B), in agreement with previous studies (17).”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [17]
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“Previous studies have shown that mito-1C–deficient cells have altered dependency on exogenous glycine due to the loss of endogenous glycine production by SHMT2 ( 17 ).”
Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth
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G2 arrest primes hematopoietic stem cells for megakaryopoiesis
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- Authors
- Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., & Rabinowitz, J. D.
- Affiliations
- Princeton University (US)
- Corresponding author
- Rabinowitz, Joshua D.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 24
- Issue
- 4
- Pages
- 640-641
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2999755403
- Cited by
- 91
- References
- 0
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 14 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 12 · 2017: 5 · 2016: 5
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007388, F32GM119195)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- one-carbon metabolism, folate metabolism, tumor growth, cell proliferation, glycine synthesis, NADPH, NADH
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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