Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills, Kathryn F., Yoshida, Shohei, Stein, Liana R., Grozio, Alessia, Kubota, Shunsuke, Sasaki, Yo, Redpath, Philip, Migaud, Marie E. +4 more·2016·Cell Metabolism

DOI 10.1016/j.cmet.2016.09.013

Cited by (932)

Items 301–400 of 932

Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases
Noemí Rotllán, Mercedes Camacho, Mireia Tondo, Elena M. G. Diarte‐Añazco, Marina Canyelles, Karen Alejandra Méndez‐Lara, Sònia Benı́tez, Núria Alonso, Dı́dac Mauricio, Joan Carles Escolá‐Gil et al. · 2021 · Antioxidants
Nicotinamide Mononucleotide Attenuates LPS-Induced Acute Lung Injury With Anti-Inflammatory, Anti-Oxidative and Anti-Apoptotic Effects
Ye Tian, Cheng‐long Zhu, Peng Li, Huiru Li, Qiang Liu, Xiaoming Deng, Jiafeng Wang · 2022 · Journal of Surgical Research
Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
Cristina Mas‐Bargues · 2023 · Free Radical Biology and Medicine
NAD + supplementation prevents STING‐induced senescence in CD8 + T cells by improving mitochondrial homeostasis
Bin Ye, Yingting Pei, Lujing Wang, Dehao Meng, Yu Zhang, Shuang Zou, Henian Li, Jinying Liu, Ziying Xie, Changhong Tian et al. · 2024 · Journal of Cellular Biochemistry
Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome
Wei-Dong Sun, Xiaojuan Zhu, Jingjing Li, Ya-Zhong Mei, Jiang-Hua Li, Jiang-Hua Li · 2024 · Frontiers in Pharmacology
Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice
Eun Roh, Gil Myoung Kang, So Young Gil, Chan Hee Lee, Seongjun Kim, Hong Dugu, Gi Hoon Son, Min‐Seon Kim · 2018 · Obesity
Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?
Natalia Rybtsova, Tatiana Nikolaevna Berezina, Alexander Kagansky, Рыбцов Станислав Александрович · 2020 · Biomedicines
The effect of lactoferrin in aging: role and potential
Bing Li, Bo Zhang, Xudong Liu, Yidan Zheng, Kuntong Han, Henan Liu, Changjing Wu, Jin Li, Shuhua Fan, Weifeng Peng et al. · 2021 · Food & Function
Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help?
Francesco Visioli, Avery Ingram, Joseph S. Beckman, Kathy Ruth Magnusson, Tory M. Hagen · 2021 · Free Radical Biology and Medicine
The compensatory antioxidant response system with a focus on neuroprogressive disorders
Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Berk, Ken R. Walder, Chiara C. Bortolasci, Wolfgang Marx, Andre Ferrer Carvalho, Michael H. J. Maes · 2019 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
Nicotinamide mononucleotide supplementation rescues mitochondrial and energy metabolism functions and ameliorates inflammatory states in the ovaries of aging mice
Jinghui Liang, Feiling Huang, Xueyu Hao, Peng Zhang, Rong Chen · 2024 · MedComm
Physiological Systems in Promoting Frailty
Laís R. Perazza, Holly M. Brown‐Borg, LaDora V. Thompson · 2022 · Comprehensive physiology
NAD+ precursor supplementation in human ageing: clinical evidence and challenges
Kasper Tore Vinten, Maria M. Trętowicz, Evrim Coskun, Michel van Weeghel, Carles Cantó, Ruben Zapata Perez, Georges E. Janssens, Riekelt H. Houtkooper · 2025 · Nature Metabolism
Therapeutic potential of nicotinamide adenine dinucleotide (NAD)
Marta Arenas‐Jal, Josep Maria Suñé-Negre, Encarna García‐Montoya · 2020 · European Journal of Pharmacology
Implications of NAD + boosters in translational medicine
Baeki E. Kang, Jun‐Yong Choi, Sokrates Stein, Dongryeol Ryu · 2020 · European Journal of Clinical Investigation
Design of an in vitro multienzyme cascade system for the biosynthesis of nicotinamide mononucleotide
Cai-lian Zhou, Jiao Feng, Jing Wang, Ning Hao, Xin Wang, Kequan Chen · 2022 · Catalysis Science & Technology
Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop
Sara E Espinoza, Sundeep Khosla, Joseph A. Baur, Rafael de Cabo, Nicolas Musi · 2023 · The Journals of Gerontology Series A
NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling
Yi Jiang, Zongrui Luo, Yuanchao Gong, Yan Fu, Yongzhang Luo · 2023 · Oncogene
NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control
Shin‐ichiro Imai · 2025 · npj Aging
Established and Emerging Mechanisms of Diabetic Cardiomyopathy
Johannes Gollmer, Andreas Zirlik, Heiko Bugger · 2019 · Journal of Lipid and Atherosclerosis
Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?
Borut Poljšak, Vito Kovač, Irina Milisav · 2020 · Oxidative Medicine and Cellular Longevity
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians
Inés Sánchez-Román, Beatriz Ferrando, Camilla Myrup Holst, Jonas Mengel‐From, S Rasmussen, Mikael Thinggaard, Vilhelm A. Bohr, Kaare Christensen, Tinna Stevnsner · 2021 · GeroScience
The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae
Chuks Kenneth Odoh, Xiaojia Guo, James T. Arnone, Xueying Wang, Zongbao K. Zhao · 2022 · Biogerontology
NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies
Andrea Loreto, Christina Antoniou, Elisa Merlini, Jonathan Gilley, Michael P. Coleman · 2023 · Neuroscience Research
Nutritional supplementation in the prevention and treatment of glaucoma
Sarah G. Chaudhry, Hamish Dunn, Nicole Ann Carnt, Andrew J. R. White · 2021 · Survey of Ophthalmology
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes
Jared M. Campbell, Saabah B. Mahbub, Michael J. Bertoldo, Abbas Habibalahi, Dale Mark Goss, William J. Ledger, Robert Bruce Gilchrist, Lindsay E. Wu, Ewa Magdalena Goldys · 2022 · Biogerontology
Nicotinamide Mononucleotide Alleviates Osteoblast Senescence Induction and Promotes Bone Healing in Osteoporotic Mice
Zufu Lu, Liting Jiang, Pooria Lesani, WenJie Zhang, Ning Li, Danyang Luo, Yusi Li, Yulin Ye, Ji Bian, Guocheng Wang et al. · 2022 · The Journals of Gerontology Series A
Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs
Sven Bulterijs, Bart P. Braeckman · 2020 · Pharmaceuticals
Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT 1 activity and antioxidant gene expression in mouse cells
Fiqri Dizar Khaidizar, Yasukazu Nakahata, Akira Kume, Kyosuke Sumizawa, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho · 2017 · Genes to Cells
Hypothalamic NAD+-Sirtuin Axis: Function and Regulation
Eun Roh, Min‐Seon Kim · 2020 · Biomolecules
Small Extracellular Vesicles Derived from Adipocytes Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous NAMPT
Yongjin Sun, Xu Li, Xiaoxu Yang, Bi Chen, Wenzhi Zhang · 2021 · Oxidative Medicine and Cellular Longevity
An artificial multi-enzyme cascade biocatalysis for biomanufacturing of nicotinamide mononucleotide from starch and nicotinamide in one-pot
Qiangzi Li, Dongdong Meng, Chun You · 2022 · Enzyme and Microbial Technology
Preparation and evaluation of ovalbumin-fucoidan nanoparticles for nicotinamide mononucleotide encapsulation with enhanced stability and anti-aging activity
Shan Sun, Xuedi Zhang, Jiaxuan Li, Yu Li, Chengfu Zhou, Siyuan Xiang, Mingqian Tan · 2023 · Food Chemistry
Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects
Kim Han, Komudi Singh, Allison M. Meadows, Rahul Sharma, Shahin Hassanzadeh, Jing Wu, Haley Goss-Holmes, Rebecca D. Huffstutler, Heather Teague, Nehal N. Mehta et al. · 2023 · Cell Reports Medicine
Nicotinamide mononucleotide induces autophagy and ferroptosis via AMPK/mTOR pathway in hepatocellular carcinoma
Zhanbo Sun, Lixian Liu, Hongyuan Liang, Lingyun Zhang · 2024 · Molecular Carcinogenesis
Effect of Exercise and Oral Niacinamide Mononucleotide on Improving Mitochondrial Autophagy in Alzheimer’s Disease
Weijia Wu, Shunling Yuan, Yingzhe Tang, Xiangyuan Meng, Mei Peng, Zelin Hu, Wenfeng Liu · 2023 · Nutrients
Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide
Chuxiong Zheng, Yumeng Li, Xin Wu, Le Gao, Xiaoyi Chen · 2024 · Nutrients
Advancements in NMN biotherapy and research updates in the field of digestive system diseases
Guanyi Liao, Yuchen Xie, Hong Peng, Tianke Li, Xinsen Zou, Faguo Yue, Jinjun Guo, Li Rong · 2024 · Journal of Translational Medicine
Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons
Laurent Guillaud, Anna Garanzini, Sarah Zakhia, Sandra de la Fuente, Dimitar Dimitrov, Susan Boerner, Marco Terenzio · 2025 · Science Advances
The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule.
Christopher W. Shade · 2020 · Europe PMC (PubMed Central)
Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota
Xiaodong Zhao, Mengmeng Kong, Yilin Wang, Yingxin Mao, Hui-lian Xu, Wenxing He, Yan He, Jinsong Gu · 2023 · Biochemical and Biophysical Research Communications
Vitamin B3 forms as precursors to NAD+: Are they safe?
Borut Poljšak, Irina Milisav · 2018 · Trends in Food Science & Technology
Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study
Pol Grootswagers, Marco Mensink, Agnes A. M. Berendsen, Carolien P.J. Deen, Ido P. Kema, Stephan J. L. Bakker, Aurelia Santoro, Claudio Franceschi, Nathalie Meunier, Corinne Malpuech‐Brugère et al. · 2020 · American Journal of Clinical Nutrition
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
Sabina Chubanava, Iuliia E. Karavaeva, Amy M. Ehrlich, Roger M. Justicia, Astrid Linde Basse, Ivan Kulik, Emilie Dalbram, Danial Ahwazi, Samuel R. Heaselgrave, Kajetan Trôst et al. · 2025 · Cell Metabolism
Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease
Mohammed A. Assiri, Hadi Ali, John Marentette, Youngho Yun, Juan Liu, Matthew D. Hirschey, Laura M. Saba, Peter S. Harris, Kristofer S. Fritz · 2019 · Human Genomics
Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging
Idoia Gallego, Ilia Villate-Beitia, Laura Sáenz del Burgo, Gustavo Puras, José Luís Pedraz · 2022 · Pharmacological Reviews
Interacting NAD + and Cell Senescence Pathways Complicate Antiaging Therapies
Andrew R. Mendelsohn, James W. Larrick · 2019 · Rejuvenation Research
Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide
Yu, Josephine, Laybutt, David Ross, Kim, Lynn-Jee, Quek, Lake-Ee, Wu, Lindsay E., Morris, Margaret J., Youngson, Neil A. · 2021 · American Journal of Physiology-Endocrinology and Metabolism
Targeting NAD+ Metabolism to Modulate Autoimmunity and Inflammation
Jing Wu, Kim Han, Michael N. Sack · 2024 · The Journal of Immunology
NAD+ metabolism and therapeutic strategies in cardiovascular diseases
Chongxu Shi, Zhaozhi Wen, Yihang Yang, Linsheng Shi, Dong Liu · 2024 · Atherosclerosis Plus
A new clinical age of aging research
Zhen Zhang, Renlei Yang, Zhike Zi, Baohua Liu · 2024 · Trends in Endocrinology and Metabolism
SLC29A1 and SLC29A2 are human nicotinamide cell membrane transporters
Mingyang Chen, Luexiang Yuan, Binxin Chen, Hui Chang, Jun Luo, Hengbin Zhang, Zhongjian Chen, Jiao Kong, Yaodong Yi, Mengru Bai et al. · 2025 · Nature Communications
Nicotinamide Mononucleotide Administration Amends Protein Acetylome of Aged Mouse Liver
Chengting Luo, Wenxi Ding, Songbiao Zhu, Yuling Chen, Xiaohui Liu, Haiteng Deng · 2022 · Cells
Polysaccharides in Berberis dasystachya improve intestinal flora depending on the molecular weight and ameliorate type 2 diabetes in rats
Wen Zhou, Lijuan Han, Sayed Haidar Abbas Raza, Qingming Yue, Shengnan Sun, Yuxin Zhao, Lifei Lv, Yongrong Deng, Zhenzhen Yuan, Ifat Alsharif et al. · 2022 · Journal of Functional Foods
Nicotinamide mononucleotide restores oxidative stress‐related apoptosis of oocyte exposed to benzyl butyl phthalate in mice
Yi Jiang, Di Wang, Cheng Zhang, Yangyang Jiao, Yanan Pu, Rong Cheng, Chunyu Li, Yan Chen · 2023 · Cell Proliferation
Inhibition of nicotinamide dinucleotide salvage pathway counters acquired and intrinsic poly(ADP-ribose) polymerase inhibitor resistance in high-grade serous ovarian cancer
Skye Alexandre Sauriol, Eurı́dice Carmona, Molly L. Udaskin, Nikolina Radulovich, Kim Leclerc-Desaulniers, Robert K. Rottapel, Amit M. Oza, Stéphanie Lheureux, Diane Michele Provencher, Anne‐Marie Mes‐Masson · 2023 · Scientific Reports
NAMPT-Mediated NAD Biosynthesis as the Internal Timing Mechanism: In NAD+ World, Time Is Running in Its Own Way
Borut Poljšak · 2017 · Rejuvenation Research
Neuroprotective role of retinal SIRT3 against acute photo-stress
Norimitsu Ban, Yoko Ozawa, Hideto Osada, Jonathan B. Lin, Eriko Toda, 光博渡辺, Kenya Yuki, Shunsuke Kubota, Rajendra S. Apte, Kazuo Tsubota · 2017 · npj Aging and Mechanisms of Disease
Safety evaluation after acute and sub-chronic oral administration of high purity nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats
Cros, Cecile, Cannelle, Hélène, Laganier, Laurent, Grozio, Alessia, Canault, Matthias · 2021 · Food and Chemical Toxicology
Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications
Candace Benjamin, Rebecca Crews · 2024 · Metabolites
Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases
Haoyuan Deng, Ding Ding, Yu Ma, Hao Zhang, Ningning Wang, Cong Zhang, Guang Yang · 2024 · International Journal of Molecular Sciences
Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease
Joshua D. Grill, Steven P. Tam, Gaby T. Thai, Beatriz Vides, Aimee L. Pierce, Kim N. Green, Daniel L. Gillen, Edmond Teng, Sarah A. Kremen, Maryam Beigi et al. · 2024 · Neurology
Nicotinamide Protects Against Diet‐Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging
Karen Alejandra Méndez‐Lara, Elisabeth Rodríguez‐Millán, David Sebastián, Rosi Blanco‐Soto, Mercedes Camacho, Madalina Nicoleta Nan, Elena M. G. Diarte‐Añazco, Eugènia Mato, Silvia Lope‐Piedrafita, Núria Roglans et al. · 2021 · Molecular Nutrition & Food Research
The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential
Xiaokai Zhang, Yang Zhang, Aijun Sun, Junbo Ge · 2021 · Genes & Diseases
Nicotinamide mononucleotide ameliorates DNFB-induced atopic dermatitis-like symptoms in mice by blocking activation of ROS-mediated JAK2/STAT5 signaling pathway
Jiefang Gao, Liu Tang, Fei Luo, Yiyuan Zhang, Lu Chen, Hong Ding, Zudong Meng · 2022 · International Immunopharmacology
Long-term oral administration of naringenin counteracts aging-related retinal degeneration via regulation of mitochondrial dynamics and autophagy
Guiping Chen, Ling Zeng, Feng Yan, Jinyi Liu, Mengqi Qin, Feifei Wang, Xu Zhang · 2022 · Frontiers in Pharmacology
Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation
Ali Aflatounian, Valentina Rodriguez Paris, Dulama Richani, Melissa C Edwards, Blake J. Cochran, William L. Ledger, Robert Bruce Gilchrist, Michael J. Bertoldo, Lindsay E. Wu, Kirsty A. Walters · 2022 · Molecular Metabolism
NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7
Xiaotong Zhao, Manman Zhang, Jinhan Wang, Kaihua Ji, Yan Wang, Xiaohui Sun, Chang Xu, Qin Wang, Ningning He, Huijuan Song et al. · 2022 · Free Radical Biology and Medicine
Nicotinamide mononucleotides alleviated neurological impairment via anti-neuroinflammation in traumatic brain injury
Xiaolu Zhu, Cheng S. Jin, Jiangtao Yu, Ruining Liu, Haoli Ma, Yan Zhao · 2023 · International Journal of Medical Sciences
Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans
A. Augusto Peluso, Agnete Troen Lundgaard, Parizad Babaei, Felippe Mousovich‐Neto, Andrea Livia Silva Rocha, Mads V. Damgaard, Emilie Glad Bak, Thiyagarajan Gnanasekaran, Ole Lindgård Dollerup, Samuel A.J. Trammell et al. · 2023 · npj Aging
Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults
Paniz Jasbi, Janko Nikolich‐Žugich, Jeffrey S. Patterson, Kenneth S. Knox, Yan Jin, George M. Weinstock, Patricia Smith, Homer L. Twigg, Haiwei Gu · 2023 · GeroScience
Nicotinamide mononucleotide impacts HIV-1 infection by modulating immune activation in T lymphocytes and humanized mice
Yufei Mo, Ming Yue, Lok Yan Yim, Runhong Zhou, Chunhao Yu, Qiaoli Peng, Ying Zhou, Tsz‐Yat Luk, Grace Chung-Yan Lui, Huarong Huang et al. · 2023 · EBioMedicine
Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men
Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui et al. · 2024 · Endocrine Journal
Meat Intake and the Dose of Vitamin B 3 – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?
Lisa J. Hill, Adrian C. Williams · 2017 · International Journal of Tryptophan Research
The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism
Sarah Hurtado-Bagès, Iva Guberović, Marcus Buschbeck · 2018 · Frontiers in Genetics
Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats
Xiaonan Wang, Xuejun Hu, Li Zhang, Xi Xu, Takashi Sakurai · 2020 · Brain Research Bulletin
Protein acetylation in cardiac aging
Ashley Francois, Alessandro Canella, Lynn M. Marcho, Matthew S. Stratton · 2021 · Journal of Molecular and Cellular Cardiology
Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity
David M. Cartwright, Lucy A. Oakey, Rachel S. Fletcher, Craig L. Doig, Silke Heising, Dean P. Larner, Daniela Nasteska, Caitlin E Berry, Samuel R. Heaselgrave, Christian Ludwig et al. · 2021 · Journal of Endocrinology
Defining NAD(P)(H) Catabolism
Jyothi Dhuguru, Ryan W. Dellinger, Marie E. Migaud · 2023 · Nutrients
Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells
Nataliya A. Kolotyeva, Alexander A. Groshkov, Natalia A. Rozanova, Arseniy K. Berdnikov, Svetlana V. Novikova, Yulia K. Komleva, Alla Borisovna Salmina, Sergey Nikolaevich Illarioshkin, М. А. Пирадов · 2024 · Biomolecules
Sirtuin activators as an anti-aging intervention for longevity
Puja Sah, Anita K. Rai, Donkupar Syiem · 2025 · Exploration of Drug Science
In vivo itaconate tracing reveals degradation pathway and turnover kinetics
Hanna F Willenbockel, Alexander Thomas Williams, Alfredo Lucas, Mack B. Reynolds, Emeline Joulia, Maureen L. Ruchhoeft, Birte Dowerg, Pedro Cabrales, Christian M. Metallo, Thekla Cordes · 2025 · Nature Metabolism
Dynamic Aging: Channeled Through Microenvironment
Qing Tan, Na Liang, Xiaoqian Zhang, Jun Li · 2021 · Frontiers in Physiology
Visualizing the Interplay of Lipid Droplets and Protein Aggregates During Aging via a Dual-Functional Fluorescent Probe
Lingliang Long, Weiguo Liu, Peng Ruan, Xinrong Yang, Xiaodong Chen, Lulu Li, Yuan Fang, Dan He, Pan Huang, Aihua Gong et al. · 2022 · Analytical Chemistry
Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery Occlusion
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Heonuk Jeong, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, K Nishioka, Kazuno Negishi, Jun Yoshino et al. · 2022 · International Journal of Molecular Sciences
Nicotinamide riboside—A missing piece in the puzzle of exercise therapy for older adults?
Carlo Custodero, Sunil Kumar Saini, Myung‐Jun Shin, Yun Kyung Jeon, Demetra D. Christou, Mary McGrae McDermott, Christiaan Leeuwenburgh, Stephen Douglas Anton, Robert T. Mankowski · 2020 · Experimental Gerontology
Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid
Feng, Shengyu, Guo, Liuling, Wang, Hao, Yang, Shanshan, Liu, Hailiang · 2023 · Communications Biology
Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice
Jiaqiang Zhang, Le-Jia Qiu, Zhaiyi Liu, Jiaxin Liu, Bo Yu, Chengcheng Liu, Baoyin Ren, Jiaqi Zhang, Shuyao Li, Youfei Guan et al. · 2024 · Journal of Pineal Research
Introduction to Epigenetics
Renato Paro, Ueli Grossniklaus, Raffaella Santoro, Anton Wutz · 2021 · Learning materials in biosciences
Simultaneous quantification of 26 NAD-related metabolites in plasma, blood, and liver tissue using UHPLC-MS/MS
Hartmut Cuny, Esther Kristianto, Mark P. Hodson, Sally L. Dunwoodie · 2021 · Analytical Biochemistry
The Significance of NAD+ Biosynthesis Alterations in Acute Kidney Injury
Amanda J. Clark, Marie Christelle Saadé, Samir M. Parikh · 2022 · Seminars in Nephrology
Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions
Jie Zhang, Caixia Wang, Haibo Shi, Danhong Wu, Weihai Ying · 2018 · Frontiers in Cellular Neuroscience
A Glimmer of Hope: Maintain Mitochondrial Homeostasis to Mitigate Alzheimer’s Disease
Wenbo Li, Ling Kui, Demetrios I. Tsirukis, Xun Gong, Min Tang · 2020 · Aging and Disease
NAD+ and Niacin Supplementation as Possible Treatments for Glaucoma and Age-Related Macular Degeneration: A Narrative Review
Mohamed R. Gemae, Mario D. Bassi, Patrick Wang, Eric K. Chin, David R.P. Almeida · 2024 · Nutrients
Metabolic reprogramming and machine learning-guided cofactor engineering to boost nicotinamide mononucleotide production in Escherichia coli
Bo Xiong, Tianrui Yang, Zixiong Zhang, Xiang Li, Huan Yu, Lian Wang, Zixuan You, Wenbin Peng, Luyu Jin, Hao Song · 2025 · Bioresource Technology
Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective
Yu Fan, Huiying Zhao, Luo Lu, Wei Wu · 2025 · Nutrients
Aged mice exhibit widespread metabolic changes but preserved major fluxes
Jankowski, Connor S.R., Samarah, Laith Z., MacArthur, Michael R., Mitchell, Sarah J., Weilandt, Daniel R., Hunter, Craig J., Zeng, Xianfeng, McReynolds, Melanie R., Rabinowitz, Joshua D. · 2025 · Cell Metabolism
The effect of NAMPT deletion in projection neurons on the function and structure of neuromuscular junction (NMJ) in mice
Samuel Lundt, Nannan Zhang, Xiaowan Wang, Luis Polo‐Parada, Shinghua Ding · 2020 · Scientific Reports
Sirt1 Protects Subventricular Zone-Derived Neural Stem Cells from DNA Double-Strand Breaks and Contributes to Olfactory Function Maintenance in Aging Mice
Jie Ren, Xianli Wang, Chuanming Dong, Guangming Wang, Wenjun Zhang, Chunhui Cai, Minxian Qian, Danjing Yang, Bin Ling, Ke Ning et al. · 2022 · Stem Cells
Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway
Duo Ma, Linlin Hu, Jinyuan Wang, Min Luo, Aihong Liang, Xiaocan Lei, Biyun Liao, Meixiang Li, Xie Ming, Haicheng Li et al. · 2022 · Acta Biochimica et Biophysica Sinica