Combined inhibition of DYRK1A, SMAD, and trithorax pathways synergizes to induce robust replication in adult human beta cells
Wang, Peng, Karakose, Esra, Liu, Hongtao, Swartz, Ethan, Ackeifi, Courtney, Zlatanic, Viktor, Wilson, Jessica, González, Bryan J. +11 more·2019·Cell Metabolism
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- The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferationMatthew Wortham, Bastian Ramms, Chun Zeng, Jacqueline R. Benthuysen, Somesh Sai, Dennis P. Pollow, Fenfen Liu, Michael Schlichting, Austin R. Harrington, Bradley Liu et al. · 2025 · Journal of Clinical Investigation
- Mixed-Lineage Leukaemia Gene Regulates Glucose-Sensitive Gene Expression and Insulin Secretion in Pancreatic Beta CellsSatoshi Yoshino, Emi Ishida, Kazuhiko Horiguchi, Shunichi Matsumoto, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Eijiro Yamada · 2024 · International Journal of Molecular Sciences
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- Glucocorticoids: novel agents to stimulate beta-cell neogenesis?Mark A. Russell, Pia Leete · 2019 · Annals of Translational Medicine
- Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional ProfileRandy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa M. Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcı́a-Ocaña, Geming Lu · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Single Cell RNA-Seq Analysis of Regenerative Drug-Treated Human Pancreatic Islets Identifies A Cycling Alpha Cell Population As Key Beta Cell ProgenitorsEsra Karaköse, Xuedi Wang, Peng Wang, Saul Carcamo, Deniz Demircioğlu, Luca Lambertini, Olivia Wood, Randy B. Kang, Geming Lu, Donald K. Scott et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2Matthew Wortham, Bastian Ramms, Chun Zeng, Jacqueline R. Benthuysen, Somesh Sai, Dennis P. Pollow, Fenfen Liu, Michael Schlichting, Austin R. Harrington, Bradley Liu et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Engineered tools to study endocrine dysfunction of pancreasCharles G. Alver, Juan Domínguez‐Bendala, Ashutosh Agarwal · 2024 · Biophysics Reviews
- Pharmacologic stimulation of insulin granule acidification increases β-cell zinc content and augments β-cell-targeted drug deliverySooyeon Lee, Hannah P. Fraser, Rebecca C. Schugar, Haixia Xu, Timothy M. Horton, Ella A. Thomson, Julie E. Park, Xucheng Zhang, Justin P. Annes · 2025 · Journal of Biological Chemistry
- Reprogramming of pancreatic islet cells for regeneration and rejuvenationMichitada Hirano, Yasuhiro Yamada · 2023 · Current Opinion in Genetics & Development
- Human Pancreatic β Cell Regenerative Therapy: Exploring the Role of Chicoric Acid as a Phytochemical CandidateAnish Murtaja Alam Khan, Nusrat Nabi, Gholamreza Abdi, Vineet Jain, Dharmander Singh, Ozair Alam, Sayeed Ahmad, Kailash Chandra · 2024 · The Journal of Phytopharmacology
- Safety in numbers: Identifying multiple targets for beta cell proliferationGaetano Santulli · 2019 · Science Translational Medicine
- Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentiallySarah Akbib, Jordy Stichelmans, Geert M. Stangé, Zhidong Ling, Zerihun Assefa, Karine Hellemans · 2019 · PLoS ONE
- Chemical Approaches for Beta-cell BiologyAmedeo Vetere, Vishal S. Parekh, Ashley E. Modell, Veronika M. Shoba, Amit Choudhary, Bridget K. Wagner · 2022 · Royal Society of Chemistry eBooks
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- Stimulation of rodent and human beta-cell proliferation using synthetic modified mRNAs encoding cell cycle regulatorsTomáš Koblas, Kateřina Bittenglová, Pavel Abaffy, K. Zacharovová, Peter Girman, Lukáš Valihrach, Jan Kříž, F Saudek · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Heterogeneity in cell-cycle dynamics of synthetic mRNA-induced β-cell proliferationKateřina Bittenglová, K. Zacharovová, Filip Tichánek, Ivan Leontovyč, Peter Girman, Jan Kříž, F Saudek, Tomáš Koblas · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetesMario Galgani, Giuseppe Matarese · 2019 · Nature Metabolism
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- Additional file 5 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic isletsGiorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni · 2021 · Figshare
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- Human and mouse regenerative macrophages enhance beta cell survival, function, and proliferationMahdis Monajemi, Alexandra S. Craciun, Qing Bo Huang, Lei Dai, Majid Mojibian, Sarah Q. Crome, C. Bruce Verchere, Megan K. Levings · 2026 · Islets
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- Additional file 1 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic isletsGiorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Kulkarni, Rohit N. · 2021 · Figshare
- Additional file 2 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic isletsGiorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni · 2021 · Figshare
- Additional file 1 of Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profilesKang, Randy B., Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa M. Siddiq, Prashant Rajbhandari, Stewart, Andrew F., Donald K. Scott, Adolfo Garcı́a-Ocaña, Geming Lu · 2023 · Figshare
- Additional file 4 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic isletsGiorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni · 2021 · Figshare
- Additional file 3 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic isletsGiorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Kulkarni, Rohit N. · 2021 · Figshare
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