Combined inhibition of DYRK1A, SMAD, and trithorax pathways synergizes to induce robust replication in adult human beta cells

Wang, Peng, Karakose, Esra, Liu, Hongtao, Swartz, Ethan, Ackeifi, Courtney, Zlatanic, Viktor, Wilson, Jessica, González, Bryan J. +11 more·2019·Cell Metabolism

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  44. Additional file 5 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
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  48. Additional file 1 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
    Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Kulkarni, Rohit N. · 2021 · Figshare
  49. Additional file 2 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
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  50. Additional file 1 of Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles
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  51. Additional file 4 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
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  52. Additional file 3 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
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  54. Development and trend of stem cell therapy for diabetes: A comprehensive review based on Knowledge visualization analysis.
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  58. An updated patent review of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors (2020–present)
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  60. Development and trend of stem cell therapy for diabetes: a comprehensive review based on knowledge visualization
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  61. The comparative cell physiology of stem cell-derived and primary human β cells
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