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Cited by 363Mitochondrial Function and PathologyLipid metabolism and biosynthesisAdipose Tissue and Metabolism

Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

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Benador, Ilan Y., Veliova, Michaela, Liesa, Marc, Shirihai, Orian S.·2019·Cell Metabolism
DOI 10.1016/j.cmet.2019.02.011PMC PMC6476311
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Abstract

The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria revealed the capacity of the cell to produce and maintain distinct mitochondrial populations carrying disparate proteome and dissimilar capacities to oxidize fatty acids and pyruvate. With mitochondrial motility being a central parameter determining mitochondrial fusion, adherence to LDs provides a mechanism by which peridroplet mitochondria (PDM) remain segregated from cytoplasmic mitochondria (CM). The existence of metabolically distinct subpopulations provides an explanation for the capacity of mitochondria within the individual cell to be involved simultaneously in fatty acid oxidation and LD formation. The mechanisms that deploy mitochondria to the LD and the dysfunctions that result from unbalanced proportions of PDM and CM remain to be explored. Understanding the roles and regulation of mitochondrial tethering to LDs offers new points of intervention in metabolic diseases.

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  • Mitochondria are involved in both the formation and degradation of LDs in non-CNS cells.

    “mitochondria are involved in both the formation and degradation of LDs in non-CNS cells (Benador et al., 2019)”

    From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Benador et al., 2019

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Cited by

Sorted by citations

Authors
Benador, I. Y., Veliova, M., Liesa, M., & Shirihai, O. S.
Affiliations
  • Boston University (US)
  • University of California, Los Angeles (US)
Corresponding author
  • Liesa, Marc
  • Shirihai, Orian S.
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2019-04
Volume
29
Issue
4
Pages
827-835
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2019.02.011
PMC
PMC6476311
OpenAlex
W2922778385
Cited by
363
References
3
Citations by year
2026: 63 · 2025: 73 · 2024: 61 · 2023: 49 · 2022: 46 · 2021: 40 · 2020: 23 · 2019: 8
FWCI
2.62
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • NIH-NIDDK (5-R01DK099618-02, RO1DK56690)
  • UCLA Department of Medicine Chair
  • UCSD/UCLA Diabetes Research Center
  • NIH (P30 DK063491, T32-DK007201)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
lipid droplets, mitochondria, mitochondrial dynamics, mitochondrial motility, mitochondrial fusion, fatty acid oxidation, fat deposition, lipid utilization, mitochondrial heterogeneity, metabolic disorders
MeSH terms
Animals, Humans, Mitochondria, Lipid Metabolism, Mitochondrial Dynamics, Lipid Droplets

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