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Cited by 154T-cell and B-cell ImmunologyAdipokines, Inflammation, and Metabolic DiseasesPsoriasis: Treatment and Pathogenesis

Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism

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Campbell, Clarissa, Rudensky, Alexander·2020·Cell Metabolism
DOI 10.1016/j.cmet.2019.09.010PMC PMC7657366
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Abstract

Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.

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Authors
Campbell, C., & Rudensky, A.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
  • Campbell, Clarissa
  • Rudensky, Alexander
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2020-01
Volume
31
Issue
1
Pages
18-25
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2019.09.010
PMC
PMC7657366
OpenAlex
W2980198543
Cited by
154
References
84
Citations by year
2026: 10 · 2025: 36 · 2024: 23 · 2023: 28 · 2022: 19 · 2021: 25 · 2020: 13
FWCI
1.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
regulatory T cells, Foxp3, immunometabolism, tissue repair, tissue homeostasis, autoimmunity, inflammation, immunosuppression
MeSH terms
Animals, Homeostasis, Humans, Inflammation, Regeneration, Autoimmunity, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Adaptive Immunity

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