The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development

Qureshi, Rehana; Picon-Ruiz, Manuel; Aurrekoetxea-Rodriguez, Iskander; Nunes de Paiva, Vanessa; D’Amico, Massimo; Yoon, Hyunho; Radhakrishnan, Ramya; Morata-Tarifa, Cynthia; Ince, Tan; Lippman, Marc E.; Thaller, Seth R.; Rodgers, Steven E.; Kesmodel, Susan; del Mar Vivanco, Maria; Slingerland, Joyce M.

doi:10.1016/j.cmet.2020.05.008

The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development

Many inflammation-associated diseases, including cancers, increase in women after menopause and with obesity. In contrast to anti-inflammatory actions of 17β-estradiol, we find estrone, which dominates after menopause, is pro-inflammatory. In human mammary adipocytes, cytokine expression increase…