The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
Open accessAbstract
The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT). Indeed, specific lipids can harm CD8 + T cell (CTL) mitochondrial integrity, leading to defective antitumor responses. However, the extent to which lipids can affect the CTL functions and fate remains unexplored. Here, we show that linoleic acid (LA) is a major positive regulator of CTL activity by improving metabolic fitness, preventing exhaustion, and stimulating a memory-like phenotype with superior effector functions. We report that LA treatment enhances the formation of ER-mitochondria contacts (MERC), which in turn promotes calcium (Ca 2+ ) signaling, mitochondrial energetics, and CTL effector functions. As a direct consequence, the antitumor potency of LA-instructed CD8 T cells is superior in vitro and in vivo . We thus propose LA treatment as an ACT potentiator in tumor therapy.
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Metadata
- Authors
- Nava Lauson, C. B., Tiberti, S., Corsetto, P. A., Conte, F., Tyagi, P., Machwirth, M., Ebert, S., Loffreda, A., Scheller, L., Sheta, D., Mokhtari, Z., Peters, T., Raman, A. T., Greco, F., Rizzo, A. M., Beilhack, A., Signore, G., Tumino, N., Vacca, P., McDonnell, L. A., Raimondi, A., Greenberg, P. D., Huppa, J. B., Cardaci, S., Caruana, I., Rodighiero, S., Nezi, L., & Manzo, T.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 35
- Issue
- 4
- Pages
- 633-650.e9
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W4323660438
- Cited by
- 291
- References
- 133
- FWCI
- 30.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nava Lauson, C. B., Tiberti, S., Corsetto, P. A., Conte, F., Tyagi, P., Machwirth, M., Ebert, S., Loffreda, A., Scheller, L., Sheta, D., Mokhtari, Z., Peters, T., Raman, A. T., Greco, F., Rizzo, A. M., Beilhack, A., Signore, G., Tumino, N., Vacca, P., . . . Manzo, T. (2023). Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity. Cell Metabolism. https://doi.org/10.1016/j.cmet.2023.02.013
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
