How to: establish and run a stool bank
Open accessAbstract
Background Since 2013, several stool banks have been developed following publications reporting on clinical success of 'faecal microbiota transplantation' (FMT) for recurrent Clostridium difficile infections (CDI). However, protocols for donor screening, faecal suspension preparation, and transfer of the faecal suspension differ between countries and institutions. Moreover, no European consensus exists regarding the legislative aspects of the faecal suspension product. Internationally standardized recommendations about the above mentioned aspects have not yet been established. Objective In 2015, the Netherlands Donor Feces Bank (NDFB) was founded with the primary aim of providing a standardized product for the treatment of patients with recurrent CDI in the Netherlands. Standard operation procedures for donor recruitment, donor selection, donor screening, and production, storage, and distribution of frozen faecal suspensions for FMT were formulated. Results and discussion Our experience summarized in this review addresses current donor recruitment and screening, preparation of the faecal suspension, transfer of the faecal microbiota suspension, and the experiences and follow-up of the patients treated with donor faeces from the NDFB.
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Donor recruitment in routine care and clinical trials is tremendously challenging.
“Third, donor recruitment in routine care and clinical trials is tremendously challenging.”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [148]
2%-20% of potential candidates are ultimately eligible for FMT donation.
“With 2%-20% of potential candidates ultimately eligible 148”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [148]
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References 67 · Cited by 168
Research works printed but not linked: 1
- Bagdasarian N, Rao K, Malani PN. Diagnosis and treatment of Clostridium difficile in adults: a systematic review. JAMA 2015;313(4):398e408.
- Authors
- Terveer, E. M., van Beurden, Y. H., Goorhuis, A., Seegers, J. F. M. L., Bauer, M. P., van Nood, E., Dijkgraaf, M. G. W., Mulder, C. J. J., Vandenbroucke-Grauls, C. M. J. E., Verspaget, H. W., Keller, J. J., & Kuijper, E. J.
- Affiliations
- Leiden University Medical Center (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Terveer, E.M.
- Keller, J.J.
- ORCID
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 23
- Issue
- 12
- Pages
- 924-930
- ISSN
- 1198-743X (ISSN-L)
- OpenAlex
- W2616731084
- Cited by
- 168
- References
- 67
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 19 · 2023: 15 · 2022: 20 · 2021: 20 · 2020: 27 · 2019: 22 · 2018: 22 · 2017: 3
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Microbiology and Infection (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Organization for Health Research and Development (1708810011)
- LUMC
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- stool bank, fecal microbiota transplantation, recurrent Clostridium difficile infection, donor screening, donor recruitment, standard operating procedures
- MeSH terms
- Fecal Microbiota Transplantation, Feces, Humans, Netherlands, Biological Specimen Banks
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