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On the magnetic aggregation of Fe3O4 nanoparticles

Karvelas, E.G., Lampropoulos, N.K., Benos, L.T., Karakasidis, T., Sarris, I.E.·2021·Computer Methods and Programs in Biomedicine
DOI 10.1016/j.cmpb.2020.105778
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Abstract

Background and objective In-vivo MRI-guided drug delivery concept is a personalized technique towards cancer treatment. A major bottleneck of this method, is the weak magnetic response of nanoparticles. A crucial improvement is the usage of paramagnetic nanoparticles aggregates since they can easier manipulated in human arteries than isolated particles. However its significance, not a comprehensive study to estimate the mean length and time to aggregate exists. Methods The present detailed numerical study includes all major discrete and continues forces and moments of the nanoscale in a global model. The effort is given in summarizing the effects of particle diameter and concentration, and magnetic field magnitude to comprehensive relations. Therefore, several cases with nanoparticles having various diameters and concentrations are simulated as magnetic field increases. Results It is found that aggregations with maximum length equal to 2000nm can be formed. In addition, the increase of the concentration leads to a decrease in the amount of the isolated particles. Consequently, 33% of the particles are isolated for the concentration of 2.25mg/ml while 13% for the concentration of 10mg/ml. Moreover, the increase of the permanent magnetic field and diameter of particles gives rise to an asymptotic behavior in the number of isolated particles. Furthermore, the mean length of aggregates scales linear with diameter and magnetic field, however, concentration increase results in a we…

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Metadata

Authors
Karvelas, E. G., Lampropoulos, N. K., Benos, L. T., Karakasidis, T., & Sarris, I. E.
Venue
Computer Methods and Programs in Biomedicine
Publisher
Elsevier BV
Published
2021-01
Volume
198
Pages
105778
ISSN
0169-2607
DOI
10.1016/j.cmpb.2020.105778
Cited by
77
References
0
Language
en
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CoChat. (2026). Citation check: On the magnetic aggregation of Fe3O4 nanoparticles. https://app.cochat.ai/papers/10.1016/j.cmpb.2020.105778
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Karvelas, E. G., Lampropoulos, N. K., Benos, L. T., Karakasidis, T., & Sarris, I. E. (2021). On the magnetic aggregation of Fe3O4 nanoparticles. Computer Methods and Programs in Biomedicine. https://doi.org/10.1016/j.cmpb.2020.105778