Evaluation of the type I error rate when using parametric bootstrap analysis of a cluster randomized controlled trial with binary outcomes and a small number of clusters

Golzarri-Arroyo, Lilian; Dickinson, Stephanie L.; Jamshidi-Naeini, Yasaman; Zoh, Roger S.; Brown, Andrew W.; Owora, Arthur H.; Li, Peng; Oakes, J. Michael; Allison, David B.

doi:10.1016/j.cmpb.2022.106654

Evaluation of the type I error rate when using parametric bootstrap analysis of a cluster randomized controlled trial with binary outcomes and a small number of clusters

Background Cluster randomized controlled trials (cRCTs) are increasingly used but must be analyzed carefully. We conducted a simulation study to evaluate the validity of a parametric bootstrap (PB) approach with respect to the empirical type I error rate for a cRCT with binary outcomes and a smal…