Current perspectives on incentive salience and applications to clinical disorders
Open accessAbstract
Affective neuroscience research has revealed that reward contains separable components of 'liking', 'wanting', and learning. Here we focus on current 'liking' and 'wanting' findings and applications to clinical disorders. 'Liking' is the hedonic impact derived from a pleasant experience, and is amplified by opioid and related signals in discrete sites located in limbic-related brain areas. 'Wanting' refers to incentive salience, a motivation process for reward, and is mediated by larger systems involving mesocorticolimbic dopamine. Deficits in incentive salience may contribute to avolitional features of depression and related disorders, whereas deficits in hedonic impact may produce true anhedonia. Excesses in incentive salience, on the other hand, can lead to addiction, especially when narrowly focused on a particular target. Finally, a fearful form of motivational salience may even contribute to some paranoia symptoms of schizophrenia and related disorders.
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The positive valence system supports social bond formation and maintenance.
“These positive valence processes create a cycle supporting the initiation and strengthening of social bonds regulated by the mesolimbic reward circuit that activates in response to cues signaling potential social reward(16–18) (i.e., incentive salience or ‘wanting’).(19)”
Positive valence processes create a cycle supporting the initiation and strengthening of social bonds regulated by the mesolimbic reward circuit that activates in response to cues signaling potential social reward.
“These positive valence processes create a cycle supporting the initiation and strengthening of social bonds regulated by the mesolimbic reward circuit that activates in response to cues signaling potential social reward(16–18) (i.e., incentive salience or ‘wanting’).(19)”
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References 118 · Cited by 157
Research works printed but not linked: 1
- [8]Reilly S Schachtman TR Conditioned taste aversion: neural and behavioral processes Oxford University Press 2008
- Authors
- Olney, J. J., Warlow, S. M., Naffziger, E. E., & Berridge, K. C.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Olney, Jeffrey J
- Venue
- Current Opinion in Behavioral Sciences
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 22
- Pages
- 59-69
- ISSN
- 2352-1546 (ISSN-L)
- PMC
- PMC5831552
- OpenAlex
- W2793123986
- Cited by
- 157
- References
- 118
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 27 · 2023: 10 · 2022: 13 · 2021: 14 · 2020: 54 · 2019: 9 · 2018: 8 · 2013: 1
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Behavioral Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DA015188, MH063649, DA007268, DC00011, DA007281)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- incentive salience, reward processing, liking, wanting, anhedonia, avolition, depression, addiction, dopamine, mesocorticolimbic system, opioid signaling, limbic system, motivational salience, fear, paranoia, schizophrenia
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