What causes anovulation in polycystic ovary syndrome?
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Immature follicles release high levels of AMH, which further stimulate GnRH release while inhibiting FSH release.
“Immature follicles release high levels of anti‐Müllerian hormone (AMH), which further stimulate GnRH release while inhibiting FSH release (Franks & Hardy, 2020).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Franks & Hardy, 2020
Granulosa cells from small antral follicles of women with PCOS prematurely switch from FSH to LH responsiveness, indicated by elevated LH receptor expression and reduced FSH receptor expression compared with unaffected women.
“The granulosa cells from small antral follicles of women with PCOS prematurely switch from FSH to LH responsiveness, as indicated by elevated LH receptor expression and reduced FSH receptor expression compared with unaffected women (Franks & Hardy, 2020; Kanamarlapudi et al., 2016; Owens et al., 2019).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Franks & Hardy, 2020
Women with PCOS demonstrate lengthened menstrual cycles due to anovulation, absent luteal progesterone, and interrupted negative feedback on gonadotropin secretion.
“Women with PCOS demonstrate lengthened menstrual cycles, due to anovulation, absent luteal progesterone, and interrupted negative feedback on gonadotropin secretion (Franks & Hardy, 2020).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Franks & Hardy, 2020
Cites
Day, F., Karaderi, T., Jones, M. R., Meun, C., He, C., Drong, A., Kraft, P., Lin, N., Huang, H., Broer, L., et al. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007813 · Cited by 619 · see citing works
Self-citationHayes, M. G., Urbanek, M., Ehrmann, D. A., Armstrong, L. L., Lee, J. Y., Sisk, R., Karaderi, T., Barber, T. M., McCarthy, M. I., Franks, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms8502 · Cited by 478 · see citing works
Self-citationRobinson, S., Chan, S., Spacey, S., Anyaoku, V., Johnston, D. G., & Franks, S. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02262.x · Cited by 141 · see citing works
Self-citationMechanisms of intergenerational transmission of polycystic ovary syndrome
Dumesic, D. A., Hoyos, L. R., Chazenbalk, G. D., Naik, R., Padmanabhan, V., & Abbott, D. H. (2020) · Reproduction · doi:10.1530/rep-19-0197 · Cited by 101 · see citing works
Kawwass, J. F., Sanders, K. M., Loucks, T. L., Rohan, L. C., & Berga, S. L. (2017) · Human Reproduction · doi:10.1093/humrep/dex086 · Cited by 79 · see citing works
In utero Androgen Excess: A Developmental Commonality Preceding Polycystic Ovary Syndrome?
Abbott, D. H., Kraynak, M., Dumesic, D. A., & Levine, J. E. (2019) · Frontiers of Hormone Research · doi:10.1159/000494899 · Cited by 42 · see citing works
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Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification
Dapas, M., & Dunaif, A. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac001 · Cited by 300 · see citing works
Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“3.3.2 | Menstrual cycles Women with PCOS demonstrate lengthened menstrual cycles, due to anovulation, absent luteal progesterone, and interrupted negative feedback on gonadotropin secretion (Franks & Hardy, 2020).”
BackgroundInfluentialThe evolutionary biology of endometriosis
Dinsdale, N., Nepomnaschy, P., & Crespi, B. (2021) · Evolution, Medicine, and Public Health · doi:10.1093/emph/eoab008 · Cited by 53 · see citing works
- Authors
- Franks, S., & Hardy, K.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Franks, Stephen
- ORCID
- Franks, Stephen
- Venue
- Current Opinion in Endocrine and Metabolic Research
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 12
- Pages
- 59-65
- ISSN
- 2451-9650 (ISSN-L)
- OpenAlex
- W3012232466
- Cited by
- 40
- References
- 6
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 6
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Endocrine and Metabolic Research (publishedVersion)
- Funders
- Medical Research Council (G0802782, MR/M012638/1, MR/S025235/1)
- Genesis Research Trust
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- polycystic ovary syndrome, anovulation, follicle-stimulating hormone, gonadotropin regulation, anti-Müllerian hormone, neuroendocrine regulation
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