CoChat
Sign Up
Cited by 28Immunotherapy and Immune Responsesvaccines and immunoinformatics approachesTrypanosoma species research and implications

Processing and presentation of antigens derived from intracellular protozoan parasites

Open access
Goldszmid, Romina S, Sher, Alan·2010·Current Opinion in Immunology
DOI 10.1016/j.coi.2010.01.017PMC PMC2871680
Open this paper in CoChat — free account

Abstract

Control of parasitic protozoan infections requires the generation of efficient innate and adaptive immune responses, and in most cases both CD8 and CD4 T cells are necessary for host survival. Since intracellular protozoa remodel the vacuolar compartments in which they reside, it is not obvious how their antigens enter the MHC class I and class II pathways. Studies using genetically engineered parasites have shown that host cell targeting, intracellular compartmentalization, subcellular localization of antigen within the parasite, and mechanism of invasion are important factors determining the presentation pathway utilized. The recent identification of endogenous parasite-derived CD8 T cell epitopes have helped confirm these concepts as well as provided new information on the processing pathways and the impact of parasite-stage specific antigen expression on the repertoire of responding T cells stimulated by infection. Elucidating the mechanisms governing antigen processing and presentation of intracellular protozoa may provide important insights needed for the rational design of effective vaccines.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.coi.2010.01.017

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The PSMD7 gene is involved in the processes of presenting antigens by the major histocompatibility complex (MHC) class I proteins to CD8+ T-lymphocytes.

    “This gene is involved in the processes of presenting antigens by the major histocompatibility complex (MHC) class I proteins to CD8+ T-lymphocytes (Morrot and Zavala, 2004; Goldszmid and Sher, 2010; Jordan and Hunter, 2010).”

    From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Goldszmid and Sher, 2010

    The 'Antigen presentation on MHC class I' section describes parasite antigens entering the class I pathway and eliciting CD8 T-cell responses (page not provided). But our copy does not mention PSMD7 or establish that this gene participates in that process; a search for PSMD7 found no matching passage. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

No references could be resolved yet.

Research works printed but not linked: 49

  1. [1]Sacks D Sher A Evasion of innate immunity by parasitic protozoa Nat Immunol 2002 3 1041 1047 12407413
  2. [2]Lang C Gross U Luder CG Subversion of innate and adaptive immune responses by Toxoplasma gondii Parasitol Res 2007 100 191 203 17024357
  3. [3]Casares S Richie TL Immune evasion by malaria parasites: a challenge for vaccine development Curr Opin Immunol 2009 21 321 330 19493666
  4. [4]Antoine JC Prina E Courret N Lang T Leishmania spp.: on the interactions they establish with antigen-presenting cells of their mammalian hosts Adv Parasitol 2004 58 1 68 15603761
  5. [5]Andrade LO Andrews NW The Trypanosoma cruzi-host-cell interplay: location, invasion, retention Nat Rev Microbiol 2005 3 819 823 16175174
  6. [6]Carruthers VB Sibley LD Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts Eur J Cell Biol 1997 73 114 123 9208224 PMC13475723
  7. [7]Sibley LD Weidner E Krahenbuhl JL Phagosome acidification blocked by intracellular Toxoplasma gondii Nature 1985 315 416 419 2860567
  8. [8]Joiner KA Fuhrman SA Miettinen HM Kasper LH Mellman I Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts Science 1990 249 641 646 2200126
  9. [9]Garg N Nunes MP Tarleton RL Delivery by Trypanosoma cruzi of proteins into the MHC class I antigen processing and presentation pathway J Immunol 1997 158 3293 3302 9120286
  10. [10]Kwok LY Lutjen S Soltek S Soldati D Busch D Deckert M Schluter D The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis J Immunol 2003 170 1949 1957 12574363
  11. [11]Gubbels MJ Striepen B Shastri N Turkoz M Robey EA Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii Infect Immun 2005 73 703 711 15664908 PMC547086
  12. [12]Bertholet S Debrabant A Afrin F Caler E Mendez S Tabbara KS Belkaid Y Sacks DL Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cells Infect Immun 2005 73 6620 6628 16177338 PMC1230980
  13. [13]Kumar S Tarleton RL The relative contribution of antibody production and CD8+ T cell function to immune control of Trypanosoma cruzi Parasite Immunol 1998 20 207 216 9651921
  14. Ng LG Hsu A Mandell MA Roediger B Hoeller C Mrass P Iparraguirre A Cavanagh LL Triccas JA Beverley SM Migratory dermal dendritic cells act as rapid sensors of protozoan parasites PLoS Pathog 2008 4 e1000222 Using intravital imaging this study shows that after intradermal injection some L. major parasites are phagocytosed by dermal DCs. 19043558 PMC2583051
  15. Peters NC Egen JG Secundino N Debrabant A Kimblin N Kamhawi S Lawyer P Fay MP Germain RN Sacks D In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies Science 2008 321 970 974 In this paper the authors used two photon microscopy to demonstrate that following inoculation of Leishmania into the skin by sand fly bite (the natural insect vector) neutrophils are the major cell population harbouring parasites at the inoculation site during initial infection. 18703742 PMC2606057
  16. Filipe-Santos O Pescher P Breart B Lippuner C Aebischer T Glaichenhaus N Spath GF Bousso P A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection Cell Host Microbe 2009 6 23 33 This study examines the interaction of L. major specific CD4 T cells with infected APCs in vivo at the site of infection. 19616763
  17. Bertholet S Goldszmid R Morrot A Debrabant A Afrin F Collazo-Custodio C Houde M Desjardins M Sher A Sacks D Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo J Immunol 2006 177 3525 3533 An early reference comparing Ag presentation to CD8 T cells by DCs infected with L. major or T. gondii 16951311
  18. [18]Kima PE Ruddle NH McMahon-Pratt D Presentation via the class I pathway by Leishmania amazonensis-infected macrophages of an endogenous leishmanial antigen to CD8+ T cells J Immunol 1997 159 1828 1834 9257846
  19. Dzierszinski F Pepper M Stumhofer JS LaRosa DF Wilson EH Turka LA Halonen SK Hunter CA Roos DS Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells Infect Immun 2007 75 5200 5209 This report compares the ability of professional versus non-professional APCs to cross-present T. gondii Ags and examines the role of Irgm3 in this process. 17846116 PMC2168266
  20. [20]Goldszmid RS Bafica A Jankovic D Feng CG Caspar P Winkler-Pickett R Trinchieri G Sher A TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production J Exp Med 2007 204 2591 2602 17923502 PMC2118487
  21. [21]Blanchard N Gonzalez F Schaeffer M Joncker NT Cheng T Shastri AJ Robey EA Shastri N Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum Nat Immunol 2008 9 937 944 Refs [21•• and 37••] describe for the first time naturally occurring T. gondii CD8 T cell epitopes. 18587399 PMC4976627
  22. Goldszmid RS Coppens I Lev A Caspar P Mellman I Sher A Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells J Exp Med 2009 206 399 410 This is a recent paper providing evidence for a role of ER-PV fusion in cross-presentation of T. gondii-derived Ag by DCs. 19153244 PMC2646567
  23. [23]Mordue DG Sibley LD Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry J Immunol 1997 159 4452 4459 9379044
  24. [24]Boothroyd JC Dubremetz JF Kiss and spit: the dual roles of Toxoplasma rhoptries Nat Rev Microbiol 2008 6 79 88 18059289
  25. [25]Neudeck A Stachelhaus S Nischik N Striepen B Reichmann G Fischer HG Expression variance, biochemical and immunological properties of Toxoplasma gondii dense granule protein GRA7 Microbes Infect 2002 4 581 590 12048027
  26. [26]Schwab JC Beckers CJ Joiner KA The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve Proc Natl Acad Sci U S A 1994 91 509 513 8290555 PMC42978
  27. [27]Sinai AP Webster P Joiner KA Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction J Cell Sci 1997 110 Pt 17 2117 2128 9378762
  28. [28]Gajria B Bahl A Brestelli J Dommer J Fischer S Gao X Heiges M Iodice J Kissinger JC Mackey AJ ToxoDB: an integrated Toxoplasma gondii database resource Nucleic Acids Res 2008 36 D553 556 18003657 PMC2238934
  29. [29]Ajioka JW Soldati A Soldati D Toxoplasma: Molecular and Cellular Biology Horizon Scientific Press Hethersett, England, UK 2007 202
  30. [30]Guermonprez P Saveanu L Kleijmeer M Davoust J Van Endert P Amigorena S ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells Nature 2003 425 397 402 14508489
  31. [31]Houde M Bertholet S Gagnon E Brunet S Goyette G Laplante A Princiotta MF Thibault P Sacks D Desjardins M Phagosomes are competent organelles for antigen cross-presentation Nature 2003 425 402 406 14508490
  32. [32]Ackerman AL Giodini A Cresswell P A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells Immunity 2006 25 607 617 17027300
  33. [33]Chtanova T Han SJ Schaeffer M van Dooren GG Herzmark P Striepen B Robey EA Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node Immunity 2009 31 342 355 Refs. [33••, 34 • and 35•] provide important insights into the dynamics of CD8 T cell-APC interactions in lymphoyd and brain tissue in vivo during T. gondii infection. 19699173 PMC3704215
  34. John B Harris TH Tait ED Wilson EH Gregg B Ng LG Mrass P Roos DS Dzierszinski F Weninger W Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii PLoS Pathog 2009 5 e1000505 See annotation to Ref. [33••] 19578440 PMC2700268
  35. Schaeffer M Han SJ Chtanova T van Dooren GG Herzmark P Chen Y Roysam B Striepen B Robey EA Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii J Immunol 2009 182 6379 6393 See annotation to Ref. [33••] 19414791
  36. [36]Martin DL Weatherly DB Laucella SA Cabinian MA Crim MT Sullivan S Heiges M Craven SH Rosenberg CS Collins MH CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes PLoS Pathog 2006 2 e77 16879036 PMC1526708
  37. Frickel EM Sahoo N Hopp J Gubbels MJ Craver MP Knoll LJ Ploegh HL Grotenbreg GM Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes J Infect Dis 2008 198 1625 1633 See annotation to Ref. [21••] 18922097 PMC4771975
  38. [38]Taylor GA Feng CG Sher A Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases) Microbes Infect 2007 9 1644 1651 18023232
  39. [39]Ling YM Shaw MH Ayala C Coppens I Taylor GA Ferguson DJ Yap GS Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages J Exp Med 2006 203 2063 2071 16940170 PMC2118399
  40. [40]Zhao Z Fux B Goodwin M Dunay IR Strong D Miller BC Cadwell K Delgado MA Ponpuak M Green KG Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens Cell Host Microbe 2008 4 458 469 18996346 PMC2682425
  41. [41]Zhao YO Khaminets A Hunn JP Howard JC Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death PLoS Pathog 2009 5 e1000288 19197351 PMC2629126
  42. [42]Martens S Parvanova I Zerrahn J Griffiths G Schell G Reichmann G Howard JC Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases PLoS Pathog 2005 1 e24 16304607 PMC1287907
  43. Bougneres L Helft J Tiwari S Vargas P Chang BH Chan L Campisi L Lauvau G Hugues S Kumar P A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells Immunity 2009 31 232 244 This recent study identifies a previously unappreciated role for Irgm3 and lipid bodies in cross-presentation of OVA coated-latex beads. 19699172 PMC2803012
  44. [44]Prickett S Gray PM Colpitts SL Scott P Kaye PM Smith DF In vivo recognition of ovalbumin expressed by transgenic Leishmania is determined by its subcellular localization J Immunol 2006 176 4826 4833 16585577 PMC2695601
  45. [45]Sacks D Noben-Trauth N The immunology of susceptibility and resistance to Leishmania major in mice Nat Rev Immunol 2002 2 845 858 12415308
  46. [46]Kamala T Nanda NK Protective response to Leishmania major in BALB/c mice requires antigen processing in the absence of DM J Immunol 2009 182 4882 4890 19342667 PMC3183993
  47. [47]Pepper M Dzierszinski F Crawford A Hunter CA Roos D Development of a system to study CD4+-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis Infect Immun 2004 72 7240 7246 15557649 PMC529136
  48. [48]Lang C Algner M Beinert N Gross U Luder CG Diverse mechanisms employed by Toxoplasma gondii to inhibit IFN-gamma-induced major histocompatibility complex class II gene expression Microbes Infect 2006 8 1994 2005 16824778
  49. [49]McKee AS Dzierszinski F Boes M Roos DS Pearce EJ Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii J Immunol 2004 173 2632 2640 15294980

Cited by

Sorted by citations

Authors
Goldszmid, R. S., & Sher, A.
Affiliations
National Institutes of Health (US)
Corresponding author
Goldszmid, Romina S
ORCID
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2010-02
Volume
22
Issue
1
Pages
118-123
ISSN
0952-7915 (ISSN-L)
DOI
10.1016/j.coi.2010.01.017
PMC
PMC2871680
OpenAlex
W2071084118
Cited by
28
References
0
Citations by year
2024: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 7 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
0.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (Z99 CA999999)
  • National Institute of Allergy and Infectious Diseases
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
  • Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Keywords
antigen processing and presentation, intracellular protozoan parasites, MHC class I pathway, CTL epitopes, CD4+ T cells, host cell targeting, parasite vaccines
MeSH terms
Animals, Antigens, Protozoan, Histocompatibility Antigens, Host-Parasite Interactions, Humans, T-Lymphocytes, Antigen Presentation, Intracellular Space

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review