Reprogramming of mitochondrial metabolism by innate immunity
Abstract
The reprogramming of cellular metabolism has emerged as a major aspect of innate immune cell activation. Mitochondria, which are well known for their critical functions in cellular bioenergetics and metabolism, also serve innate immune purposes by providing specific signaling platforms. Latest advances in our understanding of innate immune receptor-mediated metabolic reprogramming have unraveled specific immune functions of mitochondrial metabolites that place mitochondrial metabolism and particularly the mitochondrial respiratory chain at the center of innate immunity. This review highlights some recent studies that support mitochondrial metabolism as major immune signaling rheostat upon microbe recognition by innate immune cells.
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Gut microbiota may regulate inflammation by interacting with mitochondria.
“gut microbiota may regulate mitochondrial metabolism [21] and inflammation [22] by interacting with mitochondria”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [22]
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References 50 · Cited by 33
- Authors
- Garaude, J.
- Affiliations
- Université de Bordeaux (FR)
- Corresponding author
- Garaude, Johan
- ORCID
- Garaude, Johan
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 56
- Pages
- 17-23
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2895415353
- Cited by
- 33
- References
- 50
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 3
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- IDEX program of the university of Bordeaux (ANR-10-IDEX-03-02)
- Bristol-Myers Squibb Foundation for Research in Immuno-Oncology
- Cancéropole-GSO
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- mitochondrial metabolism, innate immunity, metabolic reprogramming, mitochondrial respiratory chain, mitochondrial metabolites, immune signaling, innate immune receptors
- MeSH terms
- Animals, Energy Metabolism, Humans, Immunity, Innate, Mitochondria, Signal Transduction, Cell Respiration, Cellular Reprogramming
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