Cited by 70Advancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems

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Gel-embedded niosomes: Preparation, characterization and release studies of a new system for topical drug delivery

Coviello, T., Trotta, A.M., Marianecci, C., Carafa, M., Di Marzio, L., Rinaldi, F., Di Meo, C., Alhaique, F., Matricardi, P.·2015·Colloids and Surfaces B: Biointerfaces

DOI 10.1016/j.colsurfb.2014.10.060

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Abstract

In the present paper physical gels, prepared with two polysaccharides, Xanthan and Locust Bean Gum, and loaded with non-ionic surfactant vesicles, are described. The vesicles, composed by Tween20 and cholesterol or by Tween85 and Span20, were loaded with Monoammonium glycyrrhizinate for release experiments. Size and zeta (ζ)-potential of the vesicles were evaluated and the new systems were characterized by rheological and dynamo-mechanical measurements. For an appropriate comparison, a Carbopol gel and a commercial gel for topical applications were also tested. The new formulations showed mechanical properties comparable with those of the commercial product indicating their suitability for topical applications. In vitro release experiments showed that the polysaccharide network protects the integrity of the vesicles and leads to their slow release without disruption of the aggregated structures. Furthermore, being the vesicles composed of molecules possessing enhancing properties, the permeation of the loaded drugs topically delivered can be improved. Thus, the new systems combine the advantages of matrices for a modified release (polymeric component) and those of an easier permeability across the skin (vesicle components). Finally, shelf live experiments indicated that the tested gel/vesicle formulations were stable over 1 year with no need of preservatives.

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Authors: Coviello, T., Trotta, A. M., Marianecci, C., Carafa, M., Di Marzio, L., Rinaldi, F., Di Meo, C., Alhaique, F., & Matricardi, P.
Affiliations: Sapienza University of Rome (IT)
Italian Institute of Technology (IT)
Corresponding author: Carafa, M.
ORCID: Coviello, T.
Marianecci, C.
Carafa, M.
Rinaldi, F.
Alhaique, F.
Matricardi, P.
Venue: Colloids and Surfaces B: Biointerfaces
Publisher: Elsevier BV
Published: 2015-01
Volume: 125
Pages: 291-299
ISSN: 0927-7765 (ISSN-L)
DOI: 10.1016/j.colsurfb.2014.10.060
OpenAlex: W2079025207
Cited by: 70
References: 46
Citations by year: 2026: 4 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 4
FWCI: 2.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Colloids and Surfaces B Biointerfaces (publishedVersion)
PubMed (publishedVersion)
Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders: University “Sapienza” (UNIV_2013) (C26A13JTRW, C26A13LMAZ)
Istituto Italiano di Tecnologia (IIT) Center
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Keywords: niosomes, topical drug delivery, xanthan gum, locust bean gum, polysaccharide hydrogels, Tween 20, Tween 85, Span 20, cholesterol, monoammonium glycyrrhizinate, vesicle release, skin permeation enhancement, rheological properties, shelf life
MeSH terms: Acrylic Resins, Administration, Topical, Anti-Inflammatory Agents, Non-Steroidal, Delayed-Action Preparations, Galactans, Gels, Hexoses, Kinetics, Liposomes, Mannans, Polysaccharides, Bacterial, Polysorbates, Solutions, Surface-Active Agents, Glycyrrhizic Acid, Plant Gums, Drug Liberation

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Gel-embedded niosomes: Preparation, characterization and release studies of a new system for topical drug delivery

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