Folic acid based carbon dot functionalized stearic acid-g-polyethyleneimine amphiphilic nanomicelle: Targeted drug delivery and imaging for triple negative breast cancer
Abstract
Development of advanced therapeutic modalities for the treatment of cancer are become a thirst area in the field of biomedical science now a day. Current therapeutic approaches to treat this fatal disease always refer to partial curability with unavoidable obstacles. Here, we have developed stearic-g-polyethyleneimine acid amphiphilic nanomicelle functionalized with folic acid-based carbon dots (CDs) for targeted anticancer drug (doxorubicin, DOX) delivery and concurrent bio-imaging for triple negative breast cancer (TNBC). Developed nanomicelle was characterized by FTIR, XRD, 1 H NMR, fluorescence spectroscopy, TEM etc. Highest DOX release from the nanomicelle was observed at slightly acidic pH. It was also found that the nanomicelle can be successfully internalized by the MDA-MB-231 cells and able to inhibit cell proliferation. The IC 50 value by free DOX against TNBC was around 10 μg/mL, whereas, DOX loaded CD functionalized stearic-g-polyethyleneimine (25 kDa) (DOX-CDSP-25) showed similar cytotoxicity on TNBC at the concentration of only 1.0 μg/mL, indicating the efficiency of the delivery system compared to that of free DOX. Scanning electron microscopy (SEM) analysis revealed the effect of DOX-CDSP-25 on MDA-MB-231 cellular morphology in 24 h. Along with, the fluorescence property offered by folic acid derived CD allowed CDSP-25 to be acted as a promising bio-imaging tool for TNBC.
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The fluorescence property offered by folic acid derived CD allowed CDSP-25 to act as a promising bioimaging tool for TNBC.
“The fluorescence property offered by folic acid derived CD allowed CDSP-25 to act as a promising bioimaging tool for TNBC (Figure 5).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [127]
Sarkar et al. developed stearic-g-polyethyleneimine acid amphiphilic nanomicelles functionalized with folic acid-based carbon dots (CDs) for targeted anticancer drug (DOX) delivery and concurrent bioimaging for triple negative breast cancer (TNBC).
“Recently, Sarkar et al. [127] developed stearic-g-polyethyleneimine acid amphiphilic nanomicelles functionalized with folic acid-based carbon dots (CDs) for targeted anticancer drug (DOX) delivery and concurrent bioimaging for triple negative breast cancer (TNBC).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [127]
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References 44 · Cited by 72
- Authors
- Sarkar, P., Ghosh, S., & Sarkar, K.
- Affiliations
- University of Calcutta (IN)
- Corresponding author
- Sarkar, Kishor
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 197
- Pages
- 111382
- ISSN
- 0927-7765 (ISSN-L)
- OpenAlex
- W3096301793
- Cited by
- 72
- References
- 44
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 14 · 2023: 20 · 2022: 10 · 2021: 9 · 2020: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Science and Engineering Research Board
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- carbon dots, folic acid, targeted drug delivery, doxorubicin, triple-negative breast cancer, pH-responsive drug release, fluorescence imaging, MDA-MB-231 cells, cytotoxicity
- MeSH terms
- Antibiotics, Antineoplastic, Carbon, Doxorubicin, Drug Carriers, Folic Acid, Humans, Micelles, Polyethyleneimine, Stearic Acids, Drug Delivery Systems, Cell Line, Tumor, Triple Negative Breast Neoplasms
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