Systems biology in neuroscience: bridging genes to cognition
Abstract
Systems biology is a new branch of biology aimed at understanding biological complexity. Genomic and proteomic methods integrated with cellular and organismal analyses allow modelling of physiological processes. Progress in understanding synapse composition and new experimental and bioinformatics methods indicate the synapse is an excellent starting point for global systems biology of the brain. A neuroscience systems biology programme, organized as a consortium, is proposed.
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Methods are now available to measure large-scale molecular, cellular, and circuit-level phenotypes, with additional methods in development.
“Methods have recently become available that permit the measurement of large-scale molecular4,5, cellular6 and circuit-level3 phenotypes, and additional methods are currently in development7.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [5]
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References 46 · Cited by 53
- Authors
- Grant, S. G.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Grant, Seth GN
- ORCID
- Grant, Seth GN
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 13
- Issue
- 5
- Pages
- 577-582
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2078872331
- Cited by
- 53
- References
- 46
- Citations by year
- 2024: 3 · 2021: 1 · 2017: 2 · 2015: 2 · 2013: 2 · 2012: 4
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Gatsby Charitable Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- systems biology, neuroscience, synapse proteome, bioinformatics, research consortium
- MeSH terms
- Animals, Cognition, Humans, Molecular Biology, Neurosciences, Systems Theory, Neural Networks, Computer
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