Epigenetic mechanisms of drug addiction
Open accessAbstract
Epigenetic regulation can mediate long-lasting changes in gene expression, which makes it an attractive mechanism for the stable behavioral abnormalities that characterize drug addiction. Recent research has unveiled numerous types of epigenetic modifications within the brain's reward circuitry in animal models of drug addiction. In this review, we summarize the latest advances in the field, focusing on histone modifications, DNA methylation, and noncoding RNAs. We also highlight several areas for future research. Unraveling the highly complex epigenetic mechanisms of addiction is adding to our understanding of this syndrome and has the potential to trigger novel approaches for better diagnosis and therapy.
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References 59 · Cited by 113
- Authors
- Feng, J., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Nestler, Eric J
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 23
- Issue
- 4
- Pages
- 521-528
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC3644540
- OpenAlex
- W2514160263
- Cited by
- 113
- References
- 59
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 9 · 2021: 4 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 25 · 2014: 13 · 2013: 4
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- drug addiction, epigenetic regulation, histone modifications, DNA methylation, non-coding RNA, brain reward system, gene expression, behavioral addiction, addiction treatment
- MeSH terms
- Animals, Histones, Humans, Gene Expression, DNA Methylation, Substance-Related Disorders, RNA, Untranslated, Epigenesis, Genetic
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