Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging
Abstract
Stem cells persist in specialized niches in the adult mammalian brain. Emerging findings highlight the complexity and heterogeneity of different compartments in the niche, as well as the presence of local signaling microdomains. Stem cell quiescence and activation are regulated not only by anchorage to the niche and diffusible signals, but also by biophysical properties, including fluid dynamics. Importantly, the adult neural stem cell niche integrates both local and systemic changes, reflecting the physiological state of the organism. Moreover niche signaling is bidirectional, with stem cells and their progeny and niche cells dynamically interacting with each other during homeostasis, regeneration and aging.
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Adult V-SVZ NSCs reside in a complex microenvironment comprising diverse cell types and local and long-range signals.
“Adult V-SVZ NSCs are set aside during embryogenesis, remaining largely quiescent until adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and reside in a complex microenvironment comprising diverse cell types and local and long-range signals (Silva-Vargas et al., 2013).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Silva-Vargas et al., 2013
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References 59 · Cited by 157
- Authors
- Silva-Vargas, V., Crouch, E. E., & Doetsch, F.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Doetsch, Fiona
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 23
- Issue
- 6
- Pages
- 935-942
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W1964428729
- Cited by
- 157
- References
- 59
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 13 · 2021: 14 · 2020: 9 · 2019: 14 · 2018: 12 · 2017: 16 · 2016: 14 · 2015: 24 · 2014: 12
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH NINDS (R21NS075610, R01NS074039)
- NYSTEM (C026401)
- NIH NICHD (T32HD055165)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adult neural stem cells, stem cell niche, stem cell quiescence, stem cell activation, fluid dynamics, niche signaling, homeostasis, regeneration, aging
- MeSH terms
- Aging, Animals, Homeostasis, Humans, Nerve Regeneration, Adult Stem Cells, Stem Cell Niche, Neurogenesis, Neural Stem Cells
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