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Cited by 29Neuroscience and Music PerceptionHearing, Cochlea, Tinnitus, GeneticsNeural dynamics and brain function

Synaptic plasticity as a cortical coding scheme

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Froemke, Robert C, Schreiner, Christoph E·2015·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2015.10.003PMC PMC4641776
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Abstract

Processing of auditory information requires constant adjustment due to alterations of the environment and changing conditions in the nervous system with age, health, and experience. Consequently, patterns of activity in cortical networks have complex dynamics over a wide range of timescales, from milliseconds to days and longer. In the primary auditory cortex (AI), multiple forms of adaptation and plasticity shape synaptic input and action potential output. However, the variance of neuronal responses has made it difficult to characterize AI receptive fields and to determine the function of AI in processing auditory information such as vocalizations. Here we describe recent studies on the temporal modulation of cortical responses and consider the relation of synaptic plasticity to neural coding.

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  • Modulation of inhibitory circuits enables more selective signal enhancement for specific cell types, synapses, and sensory inputs than does the direct excitation of principal cells.

    “Modulation of inhibitory circuits enables more selective signal enhancement for specific cell types, synapses, and sensory inputs than does the direct excitation of principal cells”

    From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Froemke & Schreiner 2015

    In ‘Synaptic mechanisms of cortical receptive field plasticity’ (page unavailable), the paper describes inhibition being modulated to enhance particular sensory responses and hypothesizes that stimulus-specific disinhibition permits plasticity in the inputs engaged by a stimulus. It does not establish the claim’s comparison with direct excitation of principal cells, or show that inhibitory modulation is more selective across cell types, synapses, and sensory inputs. (LLM, conf=0.83)

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Authors
Froemke, R. C., & Schreiner, C. E.
Affiliations
  • New York University (US)
  • University of California, San Francisco (US)
Corresponding author
Froemke, Robert C
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2015-12
Volume
35
Pages
185-199
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2015.10.003
PMC
PMC4641776
OpenAlex
W1951614188
Cited by
29
References
9
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 6
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIDCD (DC009635 and DC012557, DC02260)
  • Hirschl/Weill-Caulier Career Research Award
  • Sloan Research Fellowship
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
synaptic plasticity, primary auditory cortex, neural coding, receptive fields, auditory processing, vocalizations, cortical adaptation, neuronal response variability
MeSH terms
Adaptation, Physiological, Animals, Auditory Cortex, Auditory Perception, Humans, Neuronal Plasticity, Neurons

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