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Cited by 24Neuroscience and Neuropharmacology ResearchIon channel regulation and functionNeural dynamics and brain function

Homeostatic plasticity of excitability in crustacean central pattern generator networks

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Schulz, David J, Lane, Brian J·2017·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2016.09.015PMC PMC5382137
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Abstract

Plasticity of excitability can come in two general forms: changes in excitability that alter neuronal output (e.g. long-term potentiation of intrinsic excitability) or excitability changes that stabilize neuronal output (homeostatic plasticity). Here we discuss the latter form of plasticity in the context of the crustacean stomatogastric nervous system, and a second central pattern generator circuit, the cardiac ganglion. We discuss this plasticity at three levels: rapid homeostatic changes in membrane conductance, longer-term effects of neuromodulation on excitability, and the impacts of activity-dependent feedback on steady-state channel mRNA levels. We then conclude with thoughts on the implications of plasticity of excitability for variability of conductance levels across populations of motor neurons.

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  • In wild-type populations of animals with similar performance profiles, 2-7 fold variations in the mRNA expression of most cellular components are seen in identified neurons across individuals.

    “In wild-type populations of animals with similar performance profiles, 2-7 fold variations in the mRNA expression of most cellular components are seen in identified neurons across individuals [25-30]”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [27]

    The ‘Plasticity of Channel mRNA Expression’ section discusses cell-specific variation and correlations in channel transcripts in identified stomatogastric neurons. The Conclusions also describe substantial variability in ionic conductances across animals. Neither passage establishes a 2–7-fold range for mRNA expression or says that it applies to most cellular components. (LLM, conf=0.82)

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Cited by

Sorted by citations

Authors
Schulz, D. J., & Lane, B. J.
Affiliations
University of Missouri (US)
Corresponding author
Schulz, David J
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2017-04
Volume
43
Pages
7-14
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2016.09.015
PMC
PMC5382137
OpenAlex
W2529150811
Cited by
24
References
2
Citations by year
2026: 3 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 2
FWCI
0.33
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH046742)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
homeostatic plasticity, excitability, central pattern generator, stomatogastric ganglion, cardiac ganglia, crustacean nervous system, membrane conductance, neuromodulation, activity-dependent gene expression, intrinsic excitability
MeSH terms
Animals, Crustacea, Homeostasis, Motor Neurons, Nerve Net, Neuronal Plasticity, Central Pattern Generators

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