Cortical interneuron specification: the juncture of genes, time and geometry
Open accessAbstract
A fundamental question in developmental neuroscience is how hundreds of diverse cell types are generated to form specialized brain regions. The ganglionic eminences (GEs) are embryonic brain structures located in the ventral telencephalon that produce many inhibitory GABA (γ-Aminobutyric acid)-ergic cell types, including long-range projection neurons and local interneurons (INs), which disperse widely throughout the brain. While much has been discovered about the origin and wiring of these cells, a major question remains: how do neurons originating in the GEs become specified during development as one differentiated subtype versus another? This review will cover recent work that has advanced our knowledge of the mechanisms governing cortical interneuron subtype specification, particularly progenitors' spatial origin, birthdates, lineage, and mode of division.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The parvalbumin fate of PV-INs appears to be established at their origin as progenitors leave the cell cycle.
“Their 'parvalbumin' fate seems to be established at their origin, as the progenitors leave the cell cycle [127, 128].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [128]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 66 · Cited by 125
- Authors
- Bandler, R. C., Mayer, C., & Fishell, G.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Fishell, Gord
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 42
- Pages
- 17-24
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC5699457
- OpenAlex
- W2554588614
- Cited by
- 125
- References
- 66
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 17 · 2023: 12 · 2022: 7 · 2021: 15 · 2020: 13 · 2019: 9 · 2018: 15 · 2017: 15
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (NS 081297, MH095147, P01NS074972)
- Simons Foundation
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- ganglionic eminence, GABAergic neurons, inhibitory interneurons, ventral telencephalon, neuronal birthdate, neuronal lineage, cell division mode, neurogenesis
- MeSH terms
- Brain, Cell Differentiation, Humans, Interneurons, Neurons, Telencephalon
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
