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Cited by 231Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

The readily releasable pool of synaptic vesicles

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Kaeser, Pascal S, Regehr, Wade G·2017·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2016.12.012PMC PMC5447466
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Abstract

Each presynaptic bouton is densely packed with many vesicles, only a small fraction of which are available for immediate release. These vesicles constitute the readily releasable pool (RRP). The RRP size, and the probability of release of each vesicle within the RRP, together determine synaptic strength. Here, we discuss complications and recent advances in determining the size of the physiologically relevant RRP. We consider molecular mechanisms to generate and regulate the RRP, and discuss the relationship between vesicle docking and the RRP. We conclude that many RRP vesicles are docked, that some docked vesicles may not be part of the RRP, and that undocked vesicles can contribute to the RRP by rapid recruitment to unoccupied, molecularly activated ready-to-release sites.

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References 66 · Cited by 231

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Authors
Kaeser, P. S., & Regehr, W. G.
Affiliations
Harvard University (US)
Corresponding author
  • Kaeser, Pascal S
  • Regehr, Wade G
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2017-04
Volume
43
Pages
63-70
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2016.12.012
PMC
PMC5447466
OpenAlex
W2578173289
Cited by
231
References
66
Citations by year
2026: 15 · 2025: 22 · 2024: 31 · 2023: 34 · 2022: 26 · 2021: 31 · 2020: 31 · 2019: 18 · 2018: 14 · 2017: 8 · 2014: 1
FWCI
2.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH/NINDS
  • Harvard Brain Initiative Bipolar Disorder Seed Grant
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
readily releasable pool, synaptic vesicles, presynaptic terminals, vesicle docking, synaptic transmission, synaptic efficacy, vesicle recruitment, release probability, neurotransmitter release
MeSH terms
Humans, Synaptic Transmission, Synaptic Vesicles, Presynaptic Terminals

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