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Cited by 72Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital gastrointestinal and neural anomalies

Specification, plasticity and evolutionary origin of peripheral glial cells

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Kastriti, Maria Eleni, Adameyko, Igor·2017·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2017.11.004
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Abstract

Peripheral glia includes predominantly myelinating and non-myelinating Schwann cells in addition to satellite, terminal and enteric glia as well as other unresolved subtypes with localized functions. Of these subtypes, all of them originate from neural crest-derived embryonic Schwann cell precursors (SCPs). Specific gene regulatory networks control neural crest specification and downstream events, including SCP differentiation and myelination. Embryonic SCPs are multipotent and generate neuroendocrine cells, parasympathetic and enteric neurons, melanocytes and other cell types. The evolutionary origin of peripheral Schwann cell lineage is not widely discussed in the literature, despite numerous similarities between central and peripheral glia. Here, we review the major features of the Schwann cell lineage and proceed to an evolutionary discussion around possible relations between central and peripheral glial cells.

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  • OPCs are a neural-crest-like type of glia.

    “These observations, and the finding that OPCs align molecularly with all the neural-crest-derived glia, suggest that they are a neural-crest-like type of glia and support the view that they have a common evolutionary origin with Schwann cells (Kastriti and Adameyko, 2017).”

    From Molecular Architecture of the Mouse Nervous System (2018) · cites this paper as Kastriti and Adameyko, 2017

    In “Similarity of PNS glial subtypes to CNS glia” (page unavailable), the paper describes shared features of OPCs and neural-crest-derived peripheral glia, including SOX10 expression and migratory ability. It also emphasizes differences in their lineage specification, notes that OPCs lack the neural-crest-associated Foxd3, and limits proximity to the neural crest domain to a dorsal OPC population. Those passages support a qualified resemblance, not a characterization of OPCs generally as a neural-crest-like type of glia. (LLM, conf=0.82)

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  • OPCs have a common evolutionary origin with Schwann cells.

    “These observations, and the finding that OPCs align molecularly with all the neural-crest-derived glia, suggest that they are a neural-crest-like type of glia and support the view that they have a common evolutionary origin with Schwann cells (Kastriti and Adameyko, 2017).”

    From Molecular Architecture of the Mouse Nervous System (2018) · cites this paper as Kastriti and Adameyko, 2017

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Research works printed but not linked: 52

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Cited by

Sorted by citations

Authors
Kastriti, M. E., & Adameyko, I.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Adameyko, Igor
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2017-12
Volume
47
Pages
196-202
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2017.11.004
OpenAlex
W2769017338
Cited by
72
References
0
Citations by year
2026: 5 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 7
FWCI
1.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords
peripheral glia, Schwann cells, satellite glia, enteric glial cells, neural crest, Schwann cell precursors, myelination, gene regulatory networks, glial plasticity
MeSH terms
Animals, Cell Differentiation, Humans, Neuroglia, Schwann Cells, Peripheral Nervous System, Cell Lineage, Neural Stem Cells

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