Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone

Klipping, Christine; Duijkers, Ingrid; Mawet, Marie; Maillard, Catherine; Bastidas, Adriana; Jost, Maud; Foidart, Jean-Michel

doi:10.1016/j.contraception.2021.01.001

Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone

OBJECTIVES To evaluate the effect on endocrine and metabolic parameters of a new combined oral contraceptive (COC) containing estetrol (E4) and drospirenone (DRSP). STUDY DESIGN Randomized, open-label, controlled, three-arm, parallel study. Healthy subjects received either E4 15 mg/DRSP 3 mg (E4/…