Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)

Sivils, Jeffrey C; Storer, Cheryl L; Galigniana, Mario D; Cox, Marc B

doi:10.1016/j.coph.2011.03.010

Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)

The large FK506-binding protein FKBP52 has been characterized as an important positive regulator of androgen, glucocorticoid and progesterone receptor signaling pathways. FKBP52 associates with receptor-Hsp90 complexes and is proposed to have roles in both receptor hormone binding and receptor su…